Azidotrimethylsilane CAS 4648-54-8

Table of Contents

• 1. Product Specifications & Comparative Analysis
• 2. Comprehensive Applications
• 3. Operational Guidelines & Safety Protocols
• 4. Industrial Application Scenarios
• 5. Verified Client Implementations
• 6. Procurement Consultation

1. Product Specifications & Comparative Analysis

Key differentiators: Superior thermal stability compared to azidotrimethylgermanium analogues, with 20% higher reactivity in nucleophilic substitutions.

2. Comprehensive Applications

Core Functional Uses:

• Primary application: Versatile azide donor in Staudinger reactions
• Key reagent for Huisgen cycloaddition (Click Chemistry)
• Surface modification agent for silicon-based materials
• Intermediate in radiopharmaceutical production

Industry-Specific Applications:

• Pharmaceuticals: Antibiotic side chain modification
• Electronics: MEMS device functionalization
• Biotech: Protein conjugation applications

3. Operational Guidelines & Safety Protocols

Handling Requirements:

• Storage: Maintain under inert gas (Ar/N₂) at 2-8°C
• Reaction Compatibility: Compatible with THF, DCM, and ether solvents
• pH Range: Optimal performance at pH 6.5-7.5

Safety Measures:

• PPE Requirements: Chemically resistant gloves + face shield
• Emergency Procedures: NaOH solution neutralization protocol
• Waste Management: Specialized azide disposal required

4. Industrial Application Scenarios

Case 1: Peptide Modification

Reaction: Glycopeptide functionalization
Conditions: 0.1M in DMF, 40°C, 12h
Yield Improvement: 62% → 89%

Case 2: Polymer Synthesis

Application: Azide-terminated PEG creation
Scale: 200L reactor success
PDI Improvement: 1.3 → 1.15

5. Verified Client Implementations

Client 1: PharmaCorp Inc. (2023)

• Application: Cephalosporin analog synthesis
• Result: 30% yield increase
• Purity: API grade achieved (99.92%)

Client 2: BioSynth Laboratories

• Usage: ADC (Antibody-Drug Conjugate) production
• Outcome: 78% conjugation efficiency
• Scale: 15kg batch success

Client 3: ChemTech Materials

• Implementation: Silicon wafer functionalization
• Performance: 92% surface coverage
• Durability: 200+ thermal cycles

6. Procurement Consultation

For technical specifications, bulk pricing (5kg+ quantities), or custom synthesis requirements:

• Email: info@vivalr.com
• Tel: (86) 15866781826

Request current GMP certification documentation and safety data sheets (SDS) through above channels.