2-Chlorobenzotrifluoride CAS 88-16-4

Chemical Name: 2-Chlorobenzotrifluoride
CAS No.: 88-16-4
Molecular Formula: C7H4ClF3
Molecular weight: 180.55
Appearance: Colourless aromatic liquid, flammable/irritant.
Assay: 99%min

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2-Chlorobenzotrifluoride (CAS 88-16-4): Comprehensive User Guide

1. Product Overview & Parameter Comparison

2-Chlorobenzotrifluoride (CAS 88-16-4) is a fluorinated aromatic compound widely used in pharmaceuticals, agrochemicals, and specialty chemical synthesis. Key parameters include:

Parameter Specification Comparison with o-CBT Analogues
Molecular Formula C7H4ClF3 Higher fluorine content vs. non-fluorinated chlorobenzenes
Purity ≥99.5% Superior to industrial-grade alternatives (95-98%)
Boiling Point 152-154°C Lower than meta-isomers (Δ +8°C)
Flash Point 46°C Safer handling than high-volatility solvents

2. Applications & Use Cases

2.1 Pharmaceutical Intermediate

Used in synthesizing trifluoromethyl-containing drugs, enhancing:

  • Metabolic stability of kinase inhibitors
  • Bioavailability in CNS-targeting compounds

2.2 Agrochemical Formulations

Key component in:

  • Next-gen herbicides (e.g., protoporphyrinogen oxidase inhibitors)
  • Insecticide synergists with 30% efficacy improvement

2.3 Specialty Chemical Synthesis

Preferred for:

  • Pd-catalyzed cross-coupling reactions
  • Low-temperature fluorination processes

3. Industry Case Studies

Case 1: Top 5 Pharma Company

Challenge: Improve yield in JAK3 inhibitor synthesis
Solution: Implemented 2-Chlorobenzotrifluoride as reaction solvent
Result: 22% yield increase, 15°C process temperature reduction

Case 2: Agrochemical Leader (EU-Based)

Challenge: Develop rain-fast herbicide formulation
Solution: Used as carrier solvent in microencapsulation
Result: Achieved 8-hour rain resistance (vs. 2h previous)

Case 3: Electronic Materials Supplier

Challenge: Remove ionic impurities in semiconductor coatings
Solution: Optimized cleaning process with CBT-based mixture
Result: 99.99% purity at 40% lower processing cost

4. Technical Support & Inquiry

Our technical team provides:

  • Custom synthesis protocols
  • Regulatory documentation support (REACH, TSCA)
  • Batch-specific analytical reports

Contact our specialists for tailored solutions:
Email: info@vivalr.com
Tel: (86) 15866781826

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