2-Chlorobenzotrifluoride (CAS 88-16-4): Comprehensive User Guide
Table of Contents
1. Product Overview & Parameter Comparison
2-Chlorobenzotrifluoride (CAS 88-16-4) is a fluorinated aromatic compound widely used in pharmaceuticals, agrochemicals, and specialty chemical synthesis. Key parameters include:
| Parameter | Specification | Comparison with o-CBT Analogues |
|---|---|---|
| Molecular Formula | C7H4ClF3 | Higher fluorine content vs. non-fluorinated chlorobenzenes |
| Purity | ≥99.5% | Superior to industrial-grade alternatives (95-98%) |
| Boiling Point | 152-154°C | Lower than meta-isomers (Δ +8°C) |
| Flash Point | 46°C | Safer handling than high-volatility solvents |
2. Applications & Use Cases
2.1 Pharmaceutical Intermediate
Used in synthesizing trifluoromethyl-containing drugs, enhancing:
- Metabolic stability of kinase inhibitors
- Bioavailability in CNS-targeting compounds
2.2 Agrochemical Formulations
Key component in:
- Next-gen herbicides (e.g., protoporphyrinogen oxidase inhibitors)
- Insecticide synergists with 30% efficacy improvement
2.3 Specialty Chemical Synthesis
Preferred for:
- Pd-catalyzed cross-coupling reactions
- Low-temperature fluorination processes
3. Industry Case Studies
Case 1: Top 5 Pharma Company
Challenge: Improve yield in JAK3 inhibitor synthesis
Solution: Implemented 2-Chlorobenzotrifluoride as reaction solvent
Result: 22% yield increase, 15°C process temperature reduction
Case 2: Agrochemical Leader (EU-Based)
Challenge: Develop rain-fast herbicide formulation
Solution: Used as carrier solvent in microencapsulation
Result: Achieved 8-hour rain resistance (vs. 2h previous)
Case 3: Electronic Materials Supplier
Challenge: Remove ionic impurities in semiconductor coatings
Solution: Optimized cleaning process with CBT-based mixture
Result: 99.99% purity at 40% lower processing cost
4. Technical Support & Inquiry
Our technical team provides:
- Custom synthesis protocols
- Regulatory documentation support (REACH, TSCA)
- Batch-specific analytical reports
Contact our specialists for tailored solutions:
Email: info@vivalr.com
Tel: (86) 15866781826
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