Table of Contents
- Product Overview & Specifications
- Key Applications & Use Cases
- Industry Case Studies (2024)
- Procurement Guidance
- Contact for Technical Consultation
Methoxypolyethylene Glycols (mPEG, CAS 9004-74-4): Product Specifications
Technical Parameters
| Parameter | mPEG 350 | mPEG 2000 | mPEG 5000 | Conventional PEG |
|---|---|---|---|---|
| Molecular Weight Range | 300-400 | 1,900-2,200 | 4,800-5,200 | 200-20,000 |
| Hydroxyl Value (mg KOH/g) | 140-160 | 28-36 | 11-14 | Variable |
| End Group Purity | >95% | >97% | >98% | N/A |
Quality Certifications
USP/NF Grade | REACH Registered | ISO 9001:2015 Certified Manufacturing
Critical Applications in Pharmaceutical & Industrial Sectors
1. Drug Delivery Systems
mPEG derivatives enable:
- PEGylation of proteins/peptides (extend circulation half-life)
- Lipid nanoparticle (LNP) formulations for mRNA vaccines
- Solubility enhancement for poorly water-soluble APIs
2. Biomedical Research
- Surface modification of medical devices
- Hydrogel matrices for 3D cell culture
- Controlled drug release microparticles
Verified Customer Implementations (2023-2024)
Case Study 1: mRNA Vaccine Excipient Development
Client: European Biopharma Company
Challenge: Required GMP-grade mPEG 2000 for stabilizing lipid nanoparticles in COVID-19 booster vaccines
Solution: Supplied 98.7% pure mPEG with full ICH Q3D elemental impurity documentation
Outcome: Achieved 12-month stability at 2-8°C storage
Case Study 2: Ophthalmic Drug Formulation
Client: US Ophthalmic Solutions Manufacturer
Challenge: Needed low-viscosity mPEG 350 for sustained-release eye drops
Solution: Customized narrow MW distribution (PDI <1.05)
Outcome: Extended corneal residence time by 3.2x vs standard PEG
Procurement Best Practices
Supplier Evaluation Criteria
| Factor | Criticality | Industry Benchmark |
|---|---|---|
| Batch-to-Batch Consistency | High | ±2% MW variation |
| Residual Catalyst Levels | Critical | <10 ppm metal content |
Request Customized Technical Support
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