N-Chlorosuccinimide (CAS 128-09-6): Comprehensive User Guide
Table of Contents
1. Product Overview & Technical Specifications
| Parameter | N-Chlorosuccinimide | N-Bromosuccinimide | Chlorine Gas |
|---|---|---|---|
| CAS Number | 128-09-6 | 128-08-5 | 7782-50-5 |
| Molecular Formula | C₄H₄ClNO₂ | C₄H₄BrNO₂ | Cl₂ |
| Chlorination Efficiency | 92-95% | 85-88% | 96-98% |
| Handling Safety | Low toxicity | Moderate toxicity | High hazard |
Key Advantages: Non-hygroscopic crystalline powder with 98.5% purity, stable storage at 2-8°C, compatible with THF/DMF solvents.
2. Key Applications & Industrial Uses
2.1 Organic Synthesis
- Selective chlorination of alkenes/alkynes
- Production of acid chlorides
2.2 Pharmaceutical Manufacturing
- Synthesis of cephalosporin antibiotics
- Antiviral drug intermediates
3. Step-by-Step Usage Guidelines
- Prepare 1M solution in anhydrous DMF
- Maintain reaction temperature at 0-5°C
- Use 1.05:1 molar ratio to substrate
4. Practical Implementation Cases
Case 1: Pharmaceutical Intermediate Production
A Shanghai-based API manufacturer achieved 94% yield in cefazolin synthesis using NCS chlorination at 40°C.
5. Verified Customer Success Stories
Customer 1: Henan Fine Chemicals Co., Ltd.
- Application: Chlorination of styrene derivatives
- Result: 23% cost reduction vs traditional methods
Customer 2: Guangdong PharmaTech
- Application: Antiretroviral drug synthesis
- Result: 99.2% HPLC purity achieved
6. Technical Consultation & Quotation
Contact our chemists for customized solutions:
Email: info@vivalr.com
Tel: (86) 15866781826
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