Ethyl 3-hydroxybenzoate CAS 7781-98-8

Chemical Name: Ethyl 3-hydroxybenzoate
CAS No.: 7781-98-8
Molecular weight: 166.17
Appearance: White crystal

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Ethyl 3-Hydroxybenzoate (CAS 7781-98-8) Comprehensive Guide

Table of Contents

1. Product Overview & Specifications

Parameter Ethyl 3-Hydroxybenzoate Comparative Analysis
CAS Number 7781-98-8 Unique identifier for global standardization
Molecular Formula C9H10O3 Simpler structure than higher esters (e.g., propyl derivatives)
Molecular Weight 166.17 g/mol Lower molecular weight improves solubility vs. butyl variants
Melting Point 71-73°C Higher thermal stability than para-isomers
Boiling Point 187-188°C at 31 mmHg Optimal for purification via distillation
Density 1.068 g/cm³ Standard for aromatic esters
Solubility Slightly soluble in water
Fully soluble in ethanol
Superior organic solvent compatibility vs. carboxylate salts

2. Applications & Industrial Uses

Pharmaceutical Intermediate: Key precursor in synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) and antimicrobial agents.

Specialty Chemicals: Used in production of liquid crystal materials and UV stabilizers for polymers.

Research Applications:

  • Mitsunobu reaction substrate for ether synthesis
  • Building block for dendritic molecule construction

3. Operational Guidelines

Storage: Maintain in sealed containers under nitrogen atmosphere at ambient temperature (15-25°C)

Handling: Use PPE including nitrile gloves and chemical goggles. Ensure adequate ventilation in processing areas.

Purification: Recrystallization from ethanol/water (3:1 v/v) yields >99% purity crystals.

4. Case Studies

Case 1: Synthesis of Ethyl 3-(2-Methylbutoxy)benzoate
Reaction yield improved from 78% to 87% using optimized Mitsunobu conditions (DIAD, PPh3, THF, 0°C→RT)

Case 2: Production Scale-up for Antipyretic Drug Intermediate
Achieved batch consistency of 99.2±0.3% purity across 10-ton production runs

5. Client Success Stories

PharmaTech Solutions (Hamburg):
Reduced intermediate production costs by 22% through our customized ethyl 3-hydroxybenzoate supply program

Advanced Materials Co., Ltd. (Tokyo):
Enabled development of heat-resistant polycarbonates with 15% improved thermal stability

6. Inquiry & Procurement

Contact our technical team for:

  • Custom synthesis services
  • Bulk pricing (25kg+ quantities)
  • Regulatory documentation support

Email: info@vivalr.com
Phone: (86) 15866781826

Package Size Purity Lead Time
1kg ≥98% 3 working days
25kg ≥99% 5 working days
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