2-Methyl-4-nitrobenzoic Acid (CAS 1975-51-5): Technical Guide & Industry Applications
Contents
- 1. Product Overview & Comparative Analysis
- 2. Industrial Applications & Functional Mechanisms
- 3. Operational Guidelines & Safety Protocols
- 4. Case Studies: Synthesis & Process Optimization
- 5. Client Success Stories: Pharma & Agrochemical Implementations
- 6. Procurement Support & Custom Synthesis Inquiry
1. Product Overview & Comparative Analysis
| Parameter | 2-Methyl-4-nitrobenzoic Acid | 3-Nitrobenzoic Acid | 4-Nitrobenzoic Acid |
|---|---|---|---|
| CAS Number | 1975-51-5 | 121-67-5 | 62-23-7 |
| Molecular Formula | C8H7NO4 | C7H5NO4 | C7H5NO4 |
| Molecular Weight | 181.15 g/mol | 167.12 g/mol | 167.12 g/mol |
| Melting Point | 158-160°C | 142-144°C | 242-244°C |
| Nitro Group Position | Para (with methyl ortho) | Meta | Para |
2. Industrial Applications & Functional Mechanisms
Pharmaceutical Intermediate: Key precursor for antihypertensive APIs through carboxyl group derivatization.
Agrochemical Synthesis: Methyl group enhances lipid solubility for systemic herbicides (e.g., nitrofen analogs).
Coordination Chemistry: Chelating agent for transition metal catalysts in cross-coupling reactions.
3. Operational Guidelines & Safety Protocols
Handling: Use NIOSH-approved respirators (N95) during bulk processing due to particulate toxicity.
Storage: Maintain in amber glass at 2-8°C under nitrogen atmosphere; shelf life 36 months.
Incompatibilities: Avoid strong oxidizers (peroxides) and reducing agents (LiAlH4).
4. Case Studies: Synthesis & Process Optimization
Case 1: Scaled production (50 kg/batch) via mixed acid nitration (H2SO4/HNO3 3:1) at 45°C with 92% yield.
Case 2: Pd/C-mediated hydrogenation to 4-amino-2-methylbenzoic acid (pharma intermediate).
5. Client Success Stories
Client A (EU Pharma): Reduced genotoxic impurities in valsartan intermediates by 78% through controlled nitration.
Client B (US Agrochemical): Achieved 15% cost reduction in pre-emergent herbicide synthesis via solvent recycling.
6. Procurement Support & Custom Synthesis Inquiry
Request technical specifications/MSDS or discuss bulk orders:
Email: info@vivalr.com
Tel: (86) 15866781826
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