diethyl (tosyloxy)methylphosphonate cas 31618-90-3

Diethyl (Tosyloxy)methylphosphonate CAS 31618-90-3: A Comprehensive Guide

1. Product Overview & Specifications

Diethyl (tosyloxy)methylphosphonate (CAS 31618-90-3) is a specialized organophosphorus compound widely used in organic synthesis. Below are its key parameters:

Comparative Analysis with Similar Compounds

2. Key Applications & Use Cases

2.1 Pharmaceutical Intermediates

Used as a phosphorylating agent in the synthesis of antiviral drugs (e.g., nucleoside analogs) and kinase inhibitors due to its ability to introduce phosphonate groups efficiently.

2.2 Agrochemical Synthesis

Critical in creating herbicidal and insecticidal compounds by enabling precise modification of phosphorus-containing moieties.

2.3 Material Science

Facilitates the development of flame-retardant polymers and specialty coatings through controlled cross-linking reactions.

3. Industry Case Studies

Case Study 1: Antiviral Drug Development

Client: A leading pharmaceutical company in Europe
Challenge: Low yield in synthesizing a nucleoside analog intermediate.
Solution: Used diethyl (tosyloxy)methylphosphonate to optimize phosphorylation, achieving a 92% yield (vs. 65% with traditional methods).

Case Study 2: Herbicide Formulation

Client: A U.S.-based agrochemical manufacturer
Challenge: Required a stable phosphonate intermediate for a new herbicide.
Solution: Integrated CAS 31618-90-3 into their synthesis route, reducing side reactions by 40% and improving batch consistency.

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