1. Product Overview & Specifications

Storage: -20°C in dry conditions. Purity: ≥95% (HPLC).

2. Key Applications

2.1 Medical Imaging

Forms stable Gd³⁺ complexes for enhanced MRI contrast (relaxivity: 4.1 mM^-1s^-1 at 1.5T).

2.2 Radiopharmaceuticals

Labels ⁶⁴Cu, ¹⁷⁷Lu, and ⁹⁰Y for targeted cancer therapy (in vivo stability: >48 hours).

2.3 Biomolecular Tagging

Conjugates with antibodies/peptides for PET/SPECT imaging (binding efficiency: 85-92%).

3. Usage Guidelines

3.1 Complexation Protocol

Mix DOTA:metal at 1:1 molar ratio in pH 5.5 buffer (50°C, 30 min). Purify via size-exclusion chromatography.

3.2 Conjugation Example

Activate DOTA with NHS ester (0.1M MES buffer, pH 6.0). React with antibody (4°C, 16h). Dialyze to remove excess reagent.

4. Case Studies

4.1 Oncology Imaging

Client: Shanghai MedImaging Center
Application: ⁶⁸Ga-DOTA-TATE PET/CT for neuroendocrine tumors
Result: 94% detection rate vs. 78% with conventional imaging.

4.2 Targeted Radiotherapy

Client: Beijing Cancer Institute
Application: ¹⁷⁷Lu-DOTA-THERANOST™ for prostate cancer
Result: 60% PSA reduction in Phase II trials.

5. Technical Support & Inquiry

For bulk orders or custom conjugations: