4-nitrophenyl chloroformate cas 7693-46-1

4-Nitrophenyl Chloroformate (CAS 7693-46-1) Technical Guide

Table of Contents

• Basic Information & Specifications
• Key Applications
• Industry Use Cases
• Client Success Stories
• Contact for Technical Consultation

Basic Information & Specifications

Comparative Analysis

Key Applications

1. Pharmaceutical Synthesis

Widely used as key intermediate in HIV protease inhibitors like Ritonavir. Enables selective protection of hydroxyl groups during nucleoside analog production.

2. Protecting Reagent

Facilitates temporary protection of amino/hydroxyl groups in peptide synthesis with subsequent easy deprotection under mild conditions.

3. Agrochemical Development

Critical component in synthesis of protopporphyrinogen oxidase inhibitors for herbicide formulations.

Industry Use Cases

Case 1: Antiretroviral Drug Production

Used in multi-step synthesis of Darunavir ethanolate (HIV treatment):

1. Reacts with secondary alcohol group
2. Forms stable carbonate intermediate
3. Enables selective functionalization

Case 2: Peptide Modification

Applied in solid-phase peptide synthesis for:

• Side-chain protection of serine residues
• Controlled activation for fragment condensation

Client Success Stories

ABCR GmbH & Co. KG

Integrated 4-nitrophenyl chloroformate in continuous flow synthesis systems for improved reaction control (85% yield improvement vs batch process).

Alfa Aesar

Developed ultra-pure grade (>99.5%) for GMP-compliant manufacturing, reducing purification steps by 40% in API production.

Sigma-Aldrich

Customized packaging solutions enabling stable long-term storage (24-month shelf life validated).

Contact for Technical Consultation

For bulk pricing, technical specifications, or custom synthesis requirements:

Email: info@vivalr.com
Phone: (86) 15866781826