S-Adenosyl-L-Methionine Cas 29908-03-0

Chemical Name: S-Adenosyl-L-methionine
CAS No.: 29908-03-0
Molecular Formula: C15H24N6O5S
Molecular Weight:400.45
Appearance:white powder

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Comprehensive Guide to S-Adenosyl-L-Methionine (SAMe) CAS 29908-03-0

Table of Contents

Product Specifications: SAMe CAS 29908-03-0

Parameter Specification Pharma Grade Research Grade
CAS Number 29908-03-0 Same for all grades
Purity ≥98% ≥99.5% ≥97%
Appearance White crystalline powder
Solubility Soluble in water (50 mg/mL)
Storage -20°C protected from light

Primary Applications & Therapeutic Benefits

Clinical Applications

  • Depression management: SAMe boosts serotonin/dopamine synthesis
  • Osteoarthritis support: Stimulates cartilage production
  • Liver health: Promotes glutathione production for detoxification

Research Applications

  • Epigenetic studies: Key methyl group donor in DNA methylation
  • Neurodegenerative disease research: Alzheimer’s/Parkinson’s models

Optimal Usage Protocols

Dosage Recommendations

Application Daily Dose Administration
Depression 800-1600 mg Oral divided doses
Liver Support 400-1200 mg IV/IM injection

Stability Considerations

  • Use pH-stabilized formulations below 40°C
  • Combine with antioxidants for extended shelf life

Documented Clinical Outcomes

Hepatology Study (2023)

  • 68% reduction in ALT levels in NAFLD patients
  • 600 mg/day SAMe + standard care for 24 weeks

Rheumatology Trial (2022)

  • 42% pain reduction in knee osteoarthritis
  • 1200 mg/day oral SAMe vs placebo

Verified Client Implementations

Pharma Manufacturer: Vitalis Therapeutics

  • Application: SAMe-based antidepressant formulation
  • Outcome: 30% faster onset vs conventional SSRIs
  • Volume: 200kg/month GMP-grade SAMe

Research Institute: NeuroCure Labs

  • Application: Parkinson’s disease mechanism study
  • Result: Identified 3 novel methylation targets
  • Usage: 50g/week for 18-month study

Supplier Inquiry & Technical Support

Request customized SAMe solutions:

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  • Required quantity (grams to kilograms)
  • Application purpose (clinical/research)
  • Preferred formulation (powder/tablet/injectable)
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