Methyl Trifluoromethanesulfonate (CAS 333-27-7): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Methyl Trifluoromethanesulfonate (CAS 333-27-7) is a high-performance alkylating agent widely used in organic synthesis. Key parameters include:
| Parameter | Value |
|---|---|
| Chemical Formula | CF3SO3CH3 |
| Molecular Weight | 188.12 g/mol |
| Appearance | Colorless liquid |
| Purity | ≥99% |
| Boiling Point | 120-122°C |
2. Key Applications & Industrial Uses
2.1 Organic Synthesis
Widely employed as methylating agent for:
- Nucleophilic substitution reactions
- Preparation of trifluoromethanesulfonates
- Synthesis of bioactive molecules
2.2 Pharmaceutical Intermediates
Critical in manufacturing:
- Antiviral drug precursors
- Kinase inhibitor intermediates
- PET radiopharmaceuticals
3. Operational Guidelines & Safety
3.1 Handling Protocols
- Use under inert atmosphere (N2 or Ar)
- Maintain temperature below 25°C
- Employ corrosion-resistant equipment
3.2 Storage Requirements
- Store in amber glass containers
- Keep at 2-8°C with desiccant
- Shelf life: 24 months unopened
4. Comparative Analysis With Alternatives
| Parameter | Methyl Triflate | Methyl Tosylate | Dimethyl Sulfate |
|---|---|---|---|
| Reactivity | High | Medium | Low |
| Stability | Excellent | Good | Poor |
5. Real-World Case Studies
Case 1: PharmaGen Co., Ltd.
Challenge: Required high-yield synthesis of neuraminidase inhibitor intermediate.
Solution: Implemented methyl triflate in nucleophilic fluorination step
Result: 92% yield improvement vs previous methods
Case 2: ChemInnovate Solutions
Challenge: Scalability issues in PET tracer production
Solution: Optimized methyl triflate-mediated radioalkylation
Result: Reduced reaction time by 40% at commercial scale
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