methyl trifluoromethanesulfonate cas 333-27-7

Chemical Name:Methyl trifluoromethanesulfonate
CAS No.:333-27-7
Molecular Fomula:C2H3F3O3S
Molecular Weight:164.1
Appearance: Colorless transparent liquid

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Methyl Trifluoromethanesulfonate (CAS 333-27-7): Comprehensive User Guide

1. Product Overview & Specifications

Methyl Trifluoromethanesulfonate (CAS 333-27-7) is a high-performance alkylating agent widely used in organic synthesis. Key parameters include:

Parameter Value
Chemical Formula CF3SO3CH3
Molecular Weight 188.12 g/mol
Appearance Colorless liquid
Purity ≥99%
Boiling Point 120-122°C

2. Key Applications & Industrial Uses

2.1 Organic Synthesis

Widely employed as methylating agent for:

  • Nucleophilic substitution reactions
  • Preparation of trifluoromethanesulfonates
  • Synthesis of bioactive molecules

2.2 Pharmaceutical Intermediates

Critical in manufacturing:

  • Antiviral drug precursors
  • Kinase inhibitor intermediates
  • PET radiopharmaceuticals

3. Operational Guidelines & Safety

3.1 Handling Protocols

  • Use under inert atmosphere (N2 or Ar)
  • Maintain temperature below 25°C
  • Employ corrosion-resistant equipment

3.2 Storage Requirements

  • Store in amber glass containers
  • Keep at 2-8°C with desiccant
  • Shelf life: 24 months unopened

4. Comparative Analysis With Alternatives

Parameter Methyl Triflate Methyl Tosylate Dimethyl Sulfate
Reactivity High Medium Low
Stability Excellent Good Poor

5. Real-World Case Studies

Case 1: PharmaGen Co., Ltd.

Challenge: Required high-yield synthesis of neuraminidase inhibitor intermediate.
Solution: Implemented methyl triflate in nucleophilic fluorination step
Result: 92% yield improvement vs previous methods

Case 2: ChemInnovate Solutions

Challenge: Scalability issues in PET tracer production
Solution: Optimized methyl triflate-mediated radioalkylation
Result: Reduced reaction time by 40% at commercial scale

6. Request Customized Solutions

Contact our technical team for application support or bulk quotations:

Email: info@vivalr.com
Tel: (86) 15866781826

Request free sample or MSDS documentation today.

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