1. Product Overview & Key Parameters

CAS No.: 86357-13-3
Molecular Formula: C₉H₁₄O₇
Molecular Weight: 234.2 g/mol
Appearance: Colorless to pale yellow liquid
Purity: ≥98% (GC)
Storage: 2-8°C in airtight containers

Parameter Comparison Table

2. Applications in Organic Synthesis

2.1 Hydroxyl Group Protection

Widely used as acetylating agent for temporary protection of hydroxyl groups during multistep syntheses of:

• Pharmaceutical intermediates
• Natural product derivatives
• Polymer precursors

2.2 Solvent for Specialty Reactions

Effective reaction medium for:

• Grignard reactions
• Nucleophilic substitutions
• Transition metal-catalyzed couplings

3. Usage Scenarios & Best Practices

3.1 Peptide Synthesis Protection

Procedure:
1. Dissolve 1 mmol substrate in 10 mL anhydrous DCM
2. Add 1.2 eq CAS 86357-13-3 under N₂ atmosphere
3. Stir at 25°C for 4-6 hours
4. Quench with saturated NaHCO₃

3.2 Carbohydrate Chemistry

Enables selective acetylation of secondary hydroxyl groups while preserving primary OH groups in monosaccharide derivatives.

4. Client Case Studies

Case 1: PharmaTech Solutions (Germany)

Challenge: Low yield (42%) in betamethasone intermediate synthesis
Solution: Implemented CAS 86357-13-3 as protecting group
Result: Yield increased to 78% with easier deprotection

Case 2: UniChem Research (USA)

Challenge: Side reactions in polyol synthesis
Solution: Used as temporary protecting agent
Result: Selectivity improved from 65% to 92%

5. Technical Inquiry & Support

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Tel: (86) 15866781826

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