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4-(Chloromethyl)benzoic Acid (CAS 1642-81-5) Overview
Chemical Specifications
| Parameter | Value |
|---|---|
| CAS Number | 1642-81-5 |
| Molecular Formula | C8H7ClO2 |
| Molecular Weight | 170.59 g/mol |
| Appearance | White crystalline powder |
| Purity | ≥98% (HPLC) |
| Melting Point | 142-145°C |
| Solubility | Soluble in DMF, DMSO; Slightly soluble in water |
Comparative Analysis
| Feature | 4-(Chloromethyl)benzoic Acid | 4-(Bromomethyl)benzoic Acid |
|---|---|---|
| Reactivity | Moderate nucleophilic substitution | Higher reactivity |
| Cost Efficiency | 15-20% lower production cost | Requires expensive bromine sources |
| Pharma Compatibility | Preferred in NSAID synthesis | Limited to specialty APIs |
Industrial Applications
Pharmaceutical Intermediates
Critical building block for:
- Proton pump inhibitors (e.g., Omeprazole derivatives)
- Non-steroidal anti-inflammatory drugs (NSAIDs)
- Anticancer drug candidates
Polymer Chemistry
Key functionality in:
- Cross-linked resin production
- Ion-exchange membrane modification
- Dendrimer scaffolding
Application Case Studies
Case 1: Antidepressant API Synthesis
Challenge: Achieve 99.5% purity in Sertraline intermediate
Solution: Optimized benzylation using 4-(chloromethyl)benzoic acid at 65°C
Result: 99.7% purity with 12% yield improvement vs traditional methods
Case 2: Water Treatment Resins
Challenge: Create heavy metal-chelating polymers
Solution: Grafted copolymer synthesis via radical polymerization
Result: 94% Pb²⁺ removal efficiency at pH 5-8
Client Success Stories
PharmaTech Solutions (Germany)
Application: Oncology drug intermediate scale-up
Volume: 850kg/month continuous supply
Feedback: “Consistent ≥98.5% purity enabled Phase III clinical success”
Polymer Innovations Inc. (USA)
Application: Proton-exchange membranes for fuel cells
Technical Support: Custom particle size distribution (10-25μm)
Outcome: 18-month stability improvement in PEM fuel cells
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Contact Our Experts
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Request:
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