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2-Bromobenzotrifluoride (CAS 392-83-6): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
2-Bromobenzotrifluoride (CAS 392-83-6) is a halogenated aromatic compound widely used in pharmaceuticals, agrochemicals, and organic synthesis. Key specifications include:
| Parameter | Value |
|---|---|
| Molecular Formula | C7H4BrF3 |
| Molecular Weight | 225.01 g/mol |
| Boiling Point | 142–144°C |
| Density | 1.658 g/cm3 |
| Appearance | Colorless to pale yellow liquid |
Comparative Analysis with Similar Compounds
| Compound | Boiling Point (°C) | Density (g/cm3) | Reactivity |
|---|---|---|---|
| 2-Bromobenzotrifluoride | 142–144 | 1.658 | High (ideal for cross-coupling) |
| 4-Bromobenzotrifluoride | 155–157 | 1.672 | Moderate |
| Bromobenzene | 156 | 1.495 | Low |
2. Applications & Detailed Uses
Pharmaceutical Intermediates
Used in Suzuki-Miyaura cross-coupling reactions to synthesize active pharmaceutical ingredients (APIs) for antiviral and anticancer drugs.
Agrochemical Synthesis
Serves as a precursor for trifluoromethyl-containing herbicides and insecticides, enhancing metabolic stability.
Material Science
Key building block for liquid crystals and fluorinated polymers with high thermal/chemical resistance.
3. Practical Use Cases
Case 1: Synthesis of Antiviral Drug Intermediate
Reaction: Pd-catalyzed coupling with boronic acid.
Conditions: 80°C, 12h, under N2.
Yield: 89% with >99% purity.
Case 2: Herbicide Development
Application: Introduced trifluoromethyl group into pyridine-based herbicide.
Result: 40% higher field efficacy vs non-fluorinated analogs.
4. Customer Success Stories
PharmaSynth Inc. (USA)
Challenge: Low yield (55%) in API intermediate synthesis.
Solution: Optimized coupling using 2-Bromobenzotrifluoride.
Outcome: Yield increased to 82%, reduced production costs by 30%.
AgroChem Solutions (Germany)
Challenge: Poor photostability in herbicide.
Solution: Incorporated CAS 392-83-6-derived intermediate.
Outcome: Field longevity extended by 2.3x.
5. Contact for Inquiries
Request pricing, samples, or technical support:
Email: info@vivalr.com
Phone: (86) 15866781826
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