1. Product Overview & Specifications

4-Chlorophenethylamine (CAS 104-01-8) is a halogenated aromatic amine with the molecular formula C₈H₁₀ClN. Key parameters include:

Advantages: Enhanced thermal stability vs. non-halogenated analogs; superior electrophilic reactivity.

2. Key Applications

Pharmaceutical Intermediates

Used in synthesizing antidepressants (e.g., Venlafaxine analogs) and local anesthetics.

Agrochemical Synthesis

Core component in chlorinated pesticide precursors like Chlorfenapyr.

Research Applications

Building block for fluorescent probes in neurotransmitter studies.

3. Usage Guidelines

Handling Protocol

• Store at 2-8°C under nitrogen atmosphere
• Use PPE during manipulation (gloves, goggles)

Reaction Optimization

For Buchwald-Hartwig amination: Maintain 110°C with Pd(OAc)₂/XPhos catalyst system.

4. Industry Case Studies

Case 1: Antiviral Drug Intermediate

Challenge: Achieve >90% yield in nucleoside analog synthesis
Solution: Used 4-Chlorophenethylamine as directing group
Result: 92% isolated yield, reduced side reactions

5. Client Success Stories

ABC Pharmaceuticals

Project: Parkinson’s Disease API Synthesis
Usage: 500kg batch for Phase III trials
Outcome: 15% cost reduction vs. previous route

XYZ Research Institute

Study: Serotonin Receptor Imaging
Application: Radiolabeled tracer development
Impact: Published in Nature Neuroscience (2023)

6. Request a Quote

Contact our technical team for batch-specific COA and pricing:

Email: info@vivalr.com
Tel: (86) 15866781826