1. Product Overview & Specifications

3-Pyridylacetic Acid Hydrochloride (CAS 6419-36-9) is a nicotine-related compound and an advanced homologue of nicotinic acid. It is widely used as a pharmaceutical intermediate, notably in the synthesis of risedronate sodium.

Comparative Analysis

This compound offers superior solubility in polar solvents (e.g., water, ethanol) compared to non-hydrochloride derivatives, enhancing its reactivity in pharmaceutical synthesis.

2. Key Applications

• Pharmaceutical Intermediate: Critical in synthesizing risedronate sodium, a bisphosphonate for osteoporosis treatment.
• Metabolic Research: Used to study nicotine metabolism pathways and endogenous metabolites.
• Chemical Synthesis: Serves as a precursor for pyridine-based ligands and catalysts.

3. Usage Scenarios

Example 1: Risedronate Sodium Production

In a controlled reactor, 3-Pyridylacetic Acid Hydrochloride is reacted with phosphorus oxychloride under nitrogen to form the active bisphosphonate moiety. Yield optimization typically exceeds 85% with purity ≥98% (HPLC).

Example 2: Analytical Reference Standard

Used as a calibration standard in LC-MS to quantify nicotine metabolites in pharmacokinetic studies, with detection limits as low as 0.1 ng/mL.

4. Client Case Studies

Case Study 1: Pharmaceutical Manufacturer (Nanjing, China)

A leading API producer integrated this compound into their risedronate sodium production line, achieving a 20% reduction in synthesis steps and 99.2% final product purity.

Case Study 2: Research Institute (Shanghai, China)

Used in metabolic pathway analysis of tobacco alkaloids, enabling publication of three peer-reviewed studies on nicotine detoxification mechanisms.

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