5-(2-Bromoethyl)-2,3-dihydrobenzofuran: Comprehensive Product Guide
Table of Contents
1. Product Overview & Specifications
5-(2-Bromoethyl)-2,3-dihydrobenzofuran (CAS: 127264-14-6) is a brominated heterocyclic compound widely used as a pharmaceutical intermediate. Key specifications include:
| Parameter | Value |
|---|---|
| Molecular Formula | C10H11BrO |
| Molecular Weight | 227.10 g/mol |
| Purity | ≥98% (HPLC) |
Comparative Analysis with Related Compounds
| Compound | CAS | Application |
|---|---|---|
| 5-Bromo-2,3-dihydrobenzofuran | 66826-78-6 | Analytical standard |
| (S)-5-Bromo-2,3-dihydrobenzofuran-3-amine HCl | 1965314-59-3 | Chiral building block |
2. Key Applications
- Pharmaceutical Synthesis: Critical intermediate in Darifenacin production (muscarinic M3 receptor antagonist for urinary incontinence).
- Organic Chemistry Research: Building block for functionalized benzofuran derivatives.
- Material Science: Precursor for brominated polymers with flame-retardant properties.
3. Synthesis Protocol & Usage
Typical Synthesis Route (83% overall yield):
- React 2,3-dihydrobenzofuran-5-acetic acid with ethyl chloroformate to form mixed anhydride.
- Reduce with sodium borohydride to yield 5-hydroxyethyl-2,3-dihydrobenzofuran.
- Brominate using N-bromosuccinimide (NBS) and triphenylphosphine.
Handling Guidelines: Store in cool (<25°C), dry conditions; avoid light exposure.
4. Client Case Studies
Case 1: Beijing Lairuisen Pharmaceutical Technology
- Application: Darifenacin intermediate synthesis
- Scale: 50 kg batch production
- Result: 99.2% purity achieved via optimized bromination
Case 2: Wuhan Huaxiang Kejie Biotechnology
- Application: Custom brominated monomer development
- Usage: 10g analytical samples for polymer R&D
- Outcome: Successful synthesis of flame-retardant polyesters
5. Inquiry & Contact
For technical specifications, pricing, or custom synthesis requirements:
- Email: info@vivalr.com
- Tel: (86) 15866781826
Our team provides:
- GMP-grade production capabilities
- Custom packaging (1g to 100kg)
- Regulatory support (REACH, FDA DMF)
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