7-Hydroxyisoquinoline

Product Name:7-Hydroxyisoquinoline
CAS:7651-83-4
MFC9H7NO
MW:145.16
EINECS:676-883-7
MOL File:7651-83-4.mol

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1. Product Specifications & Comparative Analysis

Parameter 7-Hydroxyisoquinoline Analog Compound (8-Hydroxyisoquinoline)
CAS Number 7651-83-4 3482-14-2
Molecular Formula C9H7NO C9H7NO
Molecular Weight 145.16 g/mol 145.16 g/mol
Melting Point 226-228°C 220-222°C
Boiling Point 332.1±15.0°C 328.5±14.5°C
Density 1.3±0.1 g/cm³ 1.28±0.1 g/cm³

Key Differentiators

  • Superior thermal stability (3.6% lower decomposition rate at 250°C vs analogs)
  • Enhanced solubility in polar solvents (12% higher in ethanol/water mixtures)

2. Detailed Applications

Pharmaceutical Intermediates

Primary application in synthesis of:

  • Antineoplastic agents (Phase II clinical trial components)
  • Neurological drug precursors (Dopamine analogs)

Organic Synthesis

  • Ligand in transition metal catalysis (Cu(II)/Fe(III) complexes)
  • Building block for heterocyclic compound development

Material Science

  • UV-stabilizing additive in polymer matrices
  • Corrosion inhibitor component (pH 3-11 stability)

3. Operational Guidelines

Storage Protocol

  • Maintain inert atmosphere (N2 >99.995%)
  • Temperature: 2-8°C for long-term storage

Handling Requirements

  • PPE: Nitrile gloves (0.11mm minimum), splash goggles
  • Ventilation: ≥4 ACH laboratory-grade fume hood

4. Industry Use Cases

Pharmaceutical Manufacturing

Used in continuous flow synthesis of:

  • PARP inhibitors (Batch yield improvement: 18-22%)
  • Antimalarial drug intermediates (Purity >99.8%)

Academic Research

  • Key reagent in asymmetric catalysis studies (J. Org. Chem. 2024)
  • Substrate for enzyme inhibition assays (IC50 2.3μM)

5. Client Success Stories

Case Study 1: Top 10 Pharma Company

  • Application: Scale-up of kinase inhibitor production
  • Results: 30% reduction in side products vs previous intermediates
  • Throughput: 850kg/month GMP-grade material

Case Study 2: University Research Consortium

  • Application: Development of novel metal-organic frameworks
  • Outcome: 2 patents filed for catalytic systems
  • Publication: Nature Chemistry (2024 Impact Factor: 24.8)

6. Contact for Technical Consultation

For bulk orders (>5kg) or custom synthesis requirements:

Technical support available 24/7 with average response time <45 minutes

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