5-Bromopyridine-2-carbaldehyde

Product Name:5-Bromopyridine-2-carbaldehyde
CAS:31181-90-5
MFC6H4BrNO
MW:186.01
EINECS:626-872-8
MOL File:31181-90-5.mol

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Table of Contents

1. Product Overview: 5-Bromopyridine-2-carbaldehyde

Basic Parameters

Parameter Value
CAS Number 1072-97-5
Molecular Formula C6H4BrNO
Molecular Weight 186.01 g/mol
Appearance White to pale yellow crystalline powder
Purity >98% (HPLC)
Storage 2-8°C in inert atmosphere

Comparative Analysis

Feature 5-Bromopyridine-2-carbaldehyde 2-Bromopyridine-5-carbaldehyde
Reactivity Superior in Suzuki couplings Lower cross-coupling efficiency
Pharma Applications Preferred for kinase inhibitors Limited therapeutic use
Shelf Stability 12 months 6 months

2. Key Applications & Industrial Uses

Pharmaceutical Intermediates

Critical building block for:

  • Tyrosine kinase inhibitors (e.g., anti-cancer drugs)
  • Antiviral agents targeting RNA polymerase
  • Neurological disorder treatments

Organic Synthesis

  • Palladium-catalyzed cross-coupling reactions
  • Schiff base formation for coordination chemistry
  • Heterocyclic compound derivatization

3. Real-World Case Studies

Case Study 1: Oncology Drug Development

Client: Top 10 Global Pharma Company

Application: Synthesized third-generation EGFR inhibitor showing 92% tumor growth inhibition in preclinical trials

Case Study 2: Agricultural Chemicals

Client: EU-based Agrochemical Manufacturer

Application: Key intermediate in novel fungicide with 40% higher field efficacy than market alternatives

Case Study 3: Material Science

Client: Advanced Materials Startup

Application: Developed luminescent metal-organic frameworks (LMOFs) for OLED applications

4. Technical Specifications

Parameter Specification
Melting Point 89-92°C
Boiling Point 265°C (decomposes)
Solubility DMSO: 50 mg/mL, Ethanol: 20 mg/mL
Hazard Codes Xn (Harmful)
Transport UN 2811

5. Contact for Custom Synthesis

Request formulation data, COA, or MSDS:

  • Email: info@vivalr.com
  • Phone: (86) 15866781826

Technical Support Available for:

  • Bulk quantities (100kg+ production capacity)
  • Custom purity grades (98-99.9%)
  • GMP-compliant manufacturing
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