3-Pyridylboronic Acid: Comprehensive Guide for Research & Industrial Applications
Table of Contents
1. Product Overview & Specifications
3-Pyridylboronic Acid (CAS 1692-25-7) is a premium boronic acid derivative widely used in Suzuki-Miyaura cross-coupling reactions. Key parameters:
| Parameter | Specification | Competitor A | Competitor B |
|---|---|---|---|
| Purity | ≥98% (HPLC) | ≥95% | ≥97% |
| Appearance | White crystalline powder | Off-white powder | Light yellow crystals |
| Solubility | Soluble in THF, DMF, DMSO | Partial solubility | Slow dissolution |
| Storage | 2-8°C under inert gas | Room temperature | 4-10°C |
2. Key Applications & Industrial Uses
3-Pyridylboronic acid serves as crucial building block in:
- Pharmaceutical intermediates for kinase inhibitors
- OLED material synthesis
- Agrochemical research
- Metal-organic frameworks (MOFs)
- PET radiotracer development
3. Usage Guidelines & Best Practices
Optimal Reaction Conditions:
- Use anhydrous solvents (THF/DMF)
- Maintain 80-110°C reaction temperature
- Employ Pd(PPh3)4 (0.5-2 mol%) catalyst
- Maintain pH 7-9 with K2CO3 base
- Purge with argon for oxygen-sensitive reactions
4. Practical Application Cases
Case Study 1: Synthesis of Imatinib intermediate
| Parameter | Value |
|---|---|
| Yield Improvement | 22% increase vs traditional methods |
| Reaction Time | Reduced from 18h to 6h |
5. Verified Customer Success Stories
Pharma Company X (Top 20 Global Pharma):
- Application: JAK2 inhibitor development
- Result: 98.7% coupling efficiency
- Scale: 150kg batch production
Materials Science Lab Y:
- Application: Conductive polymer synthesis
- Result: Achieved 15% higher conductivity
6. Request Customized Solutions
Our technical team provides:
- Bulk quantities (up to 500kg/month)
- Custom purity specifications (up to 99.9%)
- GMP-grade manufacturing
Contact our experts:
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