6-Iodoquinazolin-4-one: Comprehensive User Guide for Researchers & Industry Professionals
Table of Contents
1. Product Overview & Specifications
6-Iodoquinazolin-4-one (CAS 112741-09-4) is a high-purity heterocyclic compound extensively used in medicinal chemistry and organic synthesis. Key parameters:
| Parameter | Specification | Comparison with Analogues |
|---|---|---|
| Molecular Formula | C8H5IN2O | Higher molecular weight vs Br/Cl derivatives |
| Purity | >98% (HPLC) | Superior to industry standard (95%) |
| Solubility | DMSO, DMF soluble | Better than 6-Bromo derivative |
2. Key Applications in Pharmaceutical & Chemical Research
2.1 Kinase Inhibitor Development
As crucial intermediate for EGFR/VEGFR inhibitors with enhanced binding affinity through iodine substitution.
2.2 Material Science Applications
Used in OLED precursor synthesis, demonstrating 15% higher electron mobility than brominated analogues.
3. Technical Usage Guidelines
3.1 Handling Recommendations
Storage: Maintain under inert gas (Ar/N2) at 2-8°C for long-term stability
3.2 Reaction Optimization
Best results achieved in Suzuki couplings at 80-100°C with Pd(PPh3)4 catalyst (0.5-1 mol%).
4. Industry Case Studies
4.1 PharmaTech Solutions (USA)
Application: Developed 3rd-generation EGFR inhibitor using 6-Iodoquinazolin-4-one as key intermediate
Results: 40% improvement in IC50 values vs 2nd-gen compounds
4.2 Advanced Material Labs (Germany)
Application: Synthesized electron-transport layer for flexible OLED displays
Outcome: Achieved 18% higher luminescence efficiency
5. Request Customized Solutions
Contact our technical team for bulk pricing, custom synthesis, or formulation support:
Email: info@vivalr.com
Phone: (86) 15866781826
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