3-Amino-2-Bromo-6-Picoline Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | 3-Amino-2-Bromo-6-Picoline | Comparative Analogs |
|---|---|---|
| CAS Number | 126325-53-9 | 442127-50-6 (2-Amino-3-Bromo-6-Chloropyridine) |
| Molecular Formula | C6H7BrN2 | C5H4BrClN2 |
| Molecular Weight | 187.04 g/mol | 207.46 g/mol |
| Structural Features | Pyridine ring with amino (-NH2) at position 3, bromo (-Br) at position 2, methyl (-CH3) at position 6 | Chlorine substitution at position 6 |
Note: Distinctive bromo-amino-methyl configuration enables superior reactivity in cross-coupling reactions compared to chlorinated analogs.
2. Key Applications
Pharmaceutical Intermediates
- Critical precursor for kinase inhibitors (e.g., EGFR inhibitors)
- Used in synthesis of antiviral agents targeting RNA polymerase
Agrochemical Development
- Building block for neonicotinoid insecticides with enhanced selectivity
- Key component in fungicide formulations
Advanced Materials
- Ligand in organometallic catalysts for asymmetric synthesis
- Monomer for conductive polymers in OLED applications
3. Usage Guidelines
Optimal Reaction Conditions
| Process | Recommended Parameters | Yield Optimization |
|---|---|---|
| Suzuki Coupling | Pd(PPh3)4 (2 mol%), K2CO3, DME/H2O (3:1), 80°C | 85-92% yield |
| Buchwald-Hartwig Amination | XPhos Pd G3 (1.5 mol%), Cs2CO3, toluene, 100°C | 78-86% yield |
Purification Protocols
- Column chromatography: Silica gel (230-400 mesh), hexane/EtOAc gradient
- Recrystallization: Ethanol/water (4:1) at -20°C
4. Safety & Handling
| Hazard Category | Preventive Measures | Emergency Response |
|---|---|---|
| Skin Contact | Wear nitrile gloves (≥8 mil thickness) | Flush with water for 15 mins, seek medical attention |
| Inhalation Risk | Use NIOSH-approved N95 respirator | Move to fresh air immediately |
Storage: Maintain under inert atmosphere (N2 or Ar) at 2-8°C in amber glass containers
5. Client Success Stories
Case Study 1: Anticancer Drug Development
Client: Top 10 Global Pharma Company
Application: Synthesized third-generation ALK inhibitor
Result: Achieved 94% purity in final API, reduced synthesis steps by 40%
Case Study 2: Crop Protection Formulation
Client: EU-Based Agrochemical Leader
Application: Developed resistance-breaking fungicide
Result: Increased field efficacy by 63% compared to previous gen
6. Contact for Custom Solutions
Request tailored technical packages or bulk quotes:
Email: info@vivalr.com
Tel: (86) 15866781826
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