Table of Contents
- Product Specifications & Comparative Analysis
- Functional Applications
- Operational Guidelines
- Industry Use Cases
- Client Success Stories
- Commercial Inquiry
1. Product Specifications & Comparative Analysis
1.1 Key Parameters
| Parameter | Value |
|---|---|
| Chemical Name | 6-(Trifluoromethyl)pyridine-3-carboxaldehyde |
| CAS Number | 386704-12-7 |
| Molecular Formula | C7H4NOF3 |
| Molecular Weight | 175.11 g/mol |
| Boiling Point | 205.3°C |
| Melting Point | 56-60°C |
| Flash Point | 199.4°F (93°C) |
| LogP | 1.91 |
1.2 Structural Analog Comparison
| Compound | CAS | Key Differentiator |
|---|---|---|
| 6-Methoxy-3-pyridinecarboxaldehyde | 65873-72-5 | Methoxy substituent vs. trifluoromethyl group |
| 6-Chloro-4-(trifluoromethyl)nicotinic acid | 261635-77-2 | Carboxylic acid functionality |
2. Functional Applications
2.1 Pharmaceutical Intermediates
Serves as critical building block for:
- Somatostatin receptor (sst3) modulators
- Flavanone derivatives synthesis
- Kinase inhibitor development
2.2 Agrochemical Precursors
Enables production of:
- Herbicide active ingredients
- Fungicide intermediates
2.3 Material Science
Applied in:
- Liquid crystal formulations
- Coordination polymers
3. Operational Guidelines
3.1 Handling Protocols
- Storage: Maintain at 2-8°C under inert atmosphere
- Protection: Use nitrile gloves and chemical goggles
3.2 Reaction Optimization
| Process | Recommended Conditions |
|---|---|
| Nucleophilic Addition | THF solvent, -78°C to RT |
| Cross Coupling | Pd(PPh3)4 catalyst, 80°C |
4. Industry Use Cases
4.1 Drug Discovery Pipeline
Phase III anticancer candidate synthesis:
Used in sequential Suzuki-Miyaura coupling for lead optimization
4.2 Crop Protection
Integrated into systemic fungicide formulation:
Enhanced bioavailability through trifluoromethyl group
5. Client Success Stories
5.1 Pharmaceutical Innovator (Shanghai)
Achieved 92% yield improvement in:
EGFR inhibitor synthesis through optimized aldehyde activation
5.2 European Research Consortium
Developed novel PET tracer using:
Radiolabeled derivatives for diagnostic imaging
6. Commercial Inquiry
Product Customization Options
- Bulk quantities (100kg+)
- Isotope-labeled variants (13C, 2H)
- GMP-grade available
Procurement Channels
Contact our chemical solutions team:
Email: info@vivalr.com
Tel: (86) 15866781826
Request SDS documentation and current lead times through our 24/7 inquiry portal.


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