6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE

Product Name:6-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXALDEHYDE
CAS:386704-12-7
MFC7H4F3NO
MW:175.11
EINECS:627-410-8
MOL File:386704-12-7.mol

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Table of Contents

  1. Product Specifications & Comparative Analysis
  2. Functional Applications
  3. Operational Guidelines
  4. Industry Use Cases
  5. Client Success Stories
  6. Commercial Inquiry

1. Product Specifications & Comparative Analysis

1.1 Key Parameters

Parameter Value
Chemical Name 6-(Trifluoromethyl)pyridine-3-carboxaldehyde
CAS Number 386704-12-7
Molecular Formula C7H4NOF3
Molecular Weight 175.11 g/mol
Boiling Point 205.3°C
Melting Point 56-60°C
Flash Point 199.4°F (93°C)
LogP 1.91

1.2 Structural Analog Comparison

Compound CAS Key Differentiator
6-Methoxy-3-pyridinecarboxaldehyde 65873-72-5 Methoxy substituent vs. trifluoromethyl group
6-Chloro-4-(trifluoromethyl)nicotinic acid 261635-77-2 Carboxylic acid functionality

2. Functional Applications

2.1 Pharmaceutical Intermediates

Serves as critical building block for:

  • Somatostatin receptor (sst3) modulators
  • Flavanone derivatives synthesis
  • Kinase inhibitor development

2.2 Agrochemical Precursors

Enables production of:

  • Herbicide active ingredients
  • Fungicide intermediates

2.3 Material Science

Applied in:

  • Liquid crystal formulations
  • Coordination polymers

3. Operational Guidelines

3.1 Handling Protocols

  • Storage: Maintain at 2-8°C under inert atmosphere
  • Protection: Use nitrile gloves and chemical goggles

3.2 Reaction Optimization

Process Recommended Conditions
Nucleophilic Addition THF solvent, -78°C to RT
Cross Coupling Pd(PPh3)4 catalyst, 80°C

4. Industry Use Cases

4.1 Drug Discovery Pipeline

Phase III anticancer candidate synthesis:
Used in sequential Suzuki-Miyaura coupling for lead optimization

4.2 Crop Protection

Integrated into systemic fungicide formulation:
Enhanced bioavailability through trifluoromethyl group

5. Client Success Stories

5.1 Pharmaceutical Innovator (Shanghai)

Achieved 92% yield improvement in:
EGFR inhibitor synthesis through optimized aldehyde activation

5.2 European Research Consortium

Developed novel PET tracer using:
Radiolabeled derivatives for diagnostic imaging

6. Commercial Inquiry

Product Customization Options

  • Bulk quantities (100kg+)
  • Isotope-labeled variants (13C, 2H)
  • GMP-grade available

Procurement Channels

Contact our chemical solutions team:
Email: info@vivalr.com
Tel: (86) 15866781826

Request SDS documentation and current lead times through our 24/7 inquiry portal.

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