4-Phenylpiperidine

Table of Contents

• 1. Product Overview & Specifications
• 2. Key Applications
• 3. Industrial Use Cases
• 4. Client Success Stories
• 5. Request Custom Quotes

1. Product Overview & Specifications

Chemical Name: 4-Phenylpiperidine

CAS Number: 2167-77-1

Molecular Formula: C₁₁H₁₅N

Molecular Weight: 161.24 g/mol

Comparative Analysis of Commercial Suppliers

2. Key Applications

Pharmaceutical Intermediates

Critical precursor for opioid analgesics (e.g., fentanyl analogs) and antidepressants due to its piperidine scaffold.

Organic Synthesis

Used in Buchwald-Hartwig amination, reductive amination, and heterocycle construction for complex molecule assembly.

Catalyst Development

Employed as chiral ligands in asymmetric catalysis for enantioselective synthesis.

3. Industrial Use Cases

Case 1: Fentanyl Analog Synthesis

Process: N-alkylation of 4-phenylpiperidine with phenethyl bromide (Yield: 82%, Purity: 99.2%)

Case 2: Antidepressant Development

Process: Reductive amination with 2-naphthoyl chloride (IC₅₀: 12nM on SERT)

4. Client Success Stories

PharmaTech Inc (USA)

Application: Developed novel COX-2 inhibitor using 4-phenylpiperidine intermediate

Result: 40% reduction in synthesis steps vs traditional routes

BioSynth Co (Germany)

Application: Scaled-up production of SSRI drug candidates

Result: Achieved 500kg/month production with >99.5% HPLC purity

5. Request Custom Quotes

Contact our technical team for bulk pricing, regulatory documentation (CoA, MSDS), and custom synthesis options:

Email: info@vivalr.com

Phone: (86) 15866781826