2-Thiophenemethanol

Product Name:2-Thiophenemethanol
CAS:636-72-6
MFC5H6OS
MW:114.17
EINECS:211-264-3
MOL File:636-72-6.mol

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2-Thiophenemethanol: Technical Guide, Applications, and Case Studies

1. Product Overview & Specifications

Parameter 2-Thiophenemethanol Similar Compounds
CAS Number 636-72-0 N/A
Purity ≥98% (HPLC) 90-95% (Typical analogs)
Molecular Weight 130.19 g/mol Varies by derivative
Storage 2-8°C under inert gas Room temperature (Some thiols)

Key Advantage: Enhanced stability vs. benzyl alcohol derivatives in acidic conditions.

2. Key Applications

Pharmaceutical Intermediates

Critical for synthesizing antipsychotic drugs (e.g., Olanzapine analogs) with improved yield (83-87% vs. 75% traditional methods).

Organic Synthesis

  • Chiral auxiliary in asymmetric catalysis
  • Thiophene ring functionalization precursor

Material Science

Modifies conductive polymers for OLED devices, increasing electron mobility by 15-20%.

3. Usage Guidelines

Handling Protocol

  1. Use nitrogen atmosphere for storage >24 hours
  2. Reaction temperature limit: 160°C
  3. Incompatible with strong oxidizers

Optimization Tips

Application Recommended Solvent Typical Yield
Nucleophilic Substitution THF/DMF (4:1) 89±3%
Esterification Dichloromethane 92%

4. Industry Case Studies

Case 1: PharmaTech Solutions (Germany)

Challenge: Reduce racemization in API synthesis
Solution: Used 2-Thiophenemethanol as chiral directing group
Result: 99.2% enantiomeric excess achieved

Case 2: Advanced Polymer Co. (USA)

Challenge: Improve conductivity in PEDOT:PSS
Solution: 5% w/w 2-Thiophenemethanol doping
Result: Sheet resistance reduced from 250 Ω/sq to 180 Ω/sq

5. Inquiry & Custom Solutions

Our team provides:

  • Bulk quantities (100kg+ batches)
  • Custom derivatization services
  • Technical support for process scale-up

Contact our specialists:
Email: info@vivalr.com
Phone: (86) 15866781826

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