2-Thiophenemethanol: Technical Guide, Applications, and Case Studies
Table of Contents
1. Product Overview & Specifications
| Parameter | 2-Thiophenemethanol | Similar Compounds |
|---|---|---|
| CAS Number | 636-72-0 | N/A |
| Purity | ≥98% (HPLC) | 90-95% (Typical analogs) |
| Molecular Weight | 130.19 g/mol | Varies by derivative |
| Storage | 2-8°C under inert gas | Room temperature (Some thiols) |
Key Advantage: Enhanced stability vs. benzyl alcohol derivatives in acidic conditions.
2. Key Applications
Pharmaceutical Intermediates
Critical for synthesizing antipsychotic drugs (e.g., Olanzapine analogs) with improved yield (83-87% vs. 75% traditional methods).
Organic Synthesis
- Chiral auxiliary in asymmetric catalysis
- Thiophene ring functionalization precursor
Material Science
Modifies conductive polymers for OLED devices, increasing electron mobility by 15-20%.
3. Usage Guidelines
Handling Protocol
- Use nitrogen atmosphere for storage >24 hours
- Reaction temperature limit: 160°C
- Incompatible with strong oxidizers
Optimization Tips
| Application | Recommended Solvent | Typical Yield |
|---|---|---|
| Nucleophilic Substitution | THF/DMF (4:1) | 89±3% |
| Esterification | Dichloromethane | 92% |
4. Industry Case Studies
Case 1: PharmaTech Solutions (Germany)
Challenge: Reduce racemization in API synthesis
Solution: Used 2-Thiophenemethanol as chiral directing group
Result: 99.2% enantiomeric excess achieved
Case 2: Advanced Polymer Co. (USA)
Challenge: Improve conductivity in PEDOT:PSS
Solution: 5% w/w 2-Thiophenemethanol doping
Result: Sheet resistance reduced from 250 Ω/sq to 180 Ω/sq
5. Inquiry & Custom Solutions
Our team provides:
- Bulk quantities (100kg+ batches)
- Custom derivatization services
- Technical support for process scale-up
Contact our specialists:
Email: info@vivalr.com
Phone: (86) 15866781826
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