4-BROMOPYRIDIN-2-OL

Product Name:4-BROMOPYRIDIN-2-OL
CAS:36953-37-4
MFC5H4BrNO
MW:174
EINECS:
MOL File:36953-37-4.mol

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4-Bromopyridin-2-ol: Product Guide & Industry Insights

Table of Contents

1. Product Specifications & Comparative Analysis

Parameter 4-Bromopyridin-2-ol 2-Bromopyridine 2-Hydroxypyridine
CAS Number 42286-28-6 109-04-6 142-08-5
Molecular Formula C5H4BrNO C5H4BrN C5H5NO
Purity Grade ≥98% (HPLC) ≥95% ≥97%
Primary Applications Pharmaceutical intermediates, Catalytic ligands Organic synthesis Metal chelation

2. Key Applications & Functional Uses

Pharmaceutical Manufacturing

Critical intermediate in synthesizing antiviral agents and kinase inhibitors, with enhanced reactivity at the ortho position compared to pyridine derivatives.

Agrochemical Production

Enables development of advanced crop protection chemicals through bromine-mediated coupling reactions.

Materials Science

Facilitates creation of conductive polymers and metal-organic frameworks (MOFs) via its dual functional groups.

3. Operational Guidelines & Best Practices

Handling Protocol

  1. Store in inert atmosphere (N2) at 2-8°C
  2. Use dry DMF as preferred solvent for Buchwald-Hartwig couplings
  3. Maintain pH 6-8 in aqueous reactions

4. Industry Use Cases

Case 1: Antiviral Drug Synthesis

Used in 7-step synthesis of Brincidofovir analogs, achieving 82% yield improvement over traditional methods.

Case 2: Catalytic Cross-Coupling

Enabled Suzuki-Miyaura reactions with turnover numbers (TON) exceeding 105 in palladium-based systems.

5. Client Success Stories

PharmaHealth Inc. (2023)

Reduced production costs by 38% in kinase inhibitor manufacturing through optimized bromopyridinol-mediated pathways.

AgroSolutions Ltd. (2024)

Developed next-generation fungicide using our 4-Bromopyridin-2-ol, achieving 99.2% purity in final API.

6. Request Customized Solutions

Contact our technical team for:

  • Bulk pricing (100kg+ orders)
  • Custom synthesis protocols
  • Regulatory documentation support

Email: info@vivalr.com
Phone: (86) 15866781826

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