8-Chloroisoquinoline

Product Name:8-Chloroisoquinoline
CAS:34784-07-1
MFC9H6ClN
MW:163.6
EINECS:
MOL File:34784-07-1.mol

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8-Chloroisoquinoline Product Guide

Table of Contents

1. Product Overview & Specifications

Parameter Value
CAS Number 34784-07-1
Molecular Formula C9H6ClN
Molecular Weight 163.61 g/mol
Purity ≥98%
Appearance Off-white to light yellow crystalline powder
Storage 2-8°C in airtight container

Comparative Analysis

Variant CAS Number Key Difference
5-Chloroisoquinoline 5430-45-5 Chlorine position at C5
4-Bromo-8-chloroisoquinoline 1215767-86-4 Bromine substitution at C4

2. Key Applications

Pharmaceutical Intermediates

Widely used in synthesizing kinase inhibitors and neuroprotective agents. Enables precise molecular modifications in drug discovery pipelines.

Organic Synthesis

Essential precursor for cross-coupling reactions (e.g., Suzuki-Miyaura). Serves as ligand in catalytic systems for asymmetric synthesis.

Material Science

Building block for photoactive coordination polymers and OLED components.

3. Usage Scenarios

Scenario 1: Anticancer Drug Development

Used as core structure in tyrosine kinase inhibitor R&D programs. Demonstrated 72% yield improvement in lead optimization stages.

Scenario 2: Asymmetric Catalysis

Modified derivatives achieve 95% enantiomeric excess in chiral amine synthesis.

4. Client Case Studies

Case Study 1: European Pharma Leader

Client leveraged 8-chloroisoquinoline to accelerate development of third-generation EGFR inhibitors, reducing synthesis steps from 14 to 9.

Case Study 2: Asian CRO

Implemented batch-scale production (50kg/mo) for Alzheimer’s drug candidates, maintaining 99.2% purity throughout 18-month collaboration.

5. Inquiry & Contact

Request custom synthesis options or bulk pricing:

Contact Method Details
Email info@vivalr.com
Phone (86) 15866781826

Submit technical requirements for tailored solutions. Our team responds within 2 business hours.

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