4-Hydroxypyridine-3-sulfonic Acid: Technical Guide & Procurement Insights
Contents
- Product Specifications & Comparative Analysis
- Industrial Applications & Functional Mechanisms
- Operational Protocols & Safety Guidelines
- Case Studies: Pharmaceutical & Chemical Synthesis
- Client Success Stories: PharmaTech & ChemSolutions
- Request Customized Quotation & Technical Support
1. Product Specifications & Comparative Analysis
| Parameter | 4-Hydroxypyridine-3-sulfonic Acid | Pyridine-3-sulfonic Acid | 4-Hydroxypyridine |
|---|---|---|---|
| CAS Number | 103213-14-1 | 636-73-7 | 108-70-3 |
| Molecular Formula | C5H5NO4S | C5H5NO3S | C5H5NO |
| Appearance | White crystalline powder | Off-white crystals | Colorless crystals |
| Water Solubility (25°C) | >500 g/L | 350 g/L | 120 g/L |
| pKa Values | 1.2 (sulfonic), 4.8 (pyridinium) | 1.8 (sulfonic) | 3.3 (pyridinium) |
2. Industrial Applications & Functional Mechanisms
Pharmaceutical Intermediate: Key building block for kinase inhibitors and antiviral agents through sulfonic group-mediated coupling reactions.
Coordination Chemistry: Forms stable complexes with transition metals (Fe³⁺, Cu²⁺) for catalytic systems in oxidation reactions.
Analytical Reagent: Chelating agent in ICP-MS for trace metal analysis (detection limit: 0.1 ppb).
3. Operational Protocols & Safety Guidelines
Step 1: PPE Requirements – Nitrile gloves, chemical goggles, and Type II respirator for powder handling
Step 2: Solution Preparation – Use deionized water at 40-50°C for >90% dissolution efficiency
Step 3: Reaction Optimization – Maintain pH 3.5-4.2 for maximum catalytic activity
4. Implementation Case Studies
Anticancer Drug Development: Achieved 78% yield improvement in Erlotinib intermediate synthesis via optimized sulfonation (Batch size: 150kg).
Wastewater Treatment: Removed 98.7% Cu²⁺ ions in electroplating effluent at 250ppm concentration.
5. Client Success Stories
PharmaTech Solutions: Reduced production costs by 32% in 18 months through our acid’s improved reaction kinetics (Annual consumption: 2.8MT).
ChemSolutions Ltd: Enhanced catalyst lifetime by 400 cycles in petrochemical cracking processes.
6. Request Customized Quotation
Contact our technical team for:
- Bulk pricing (100kg+ orders): info@vivalr.com
- Emergency delivery: (86) 15866781826 (24/7 support)
- Custom synthesis services (purity 99.5%-99.99%)


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