3-Fluoro-5-hydroxypyridine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
3-Fluoro-5-hydroxypyridine (CAS 1072-84-6) is a fluorinated pyridine derivative widely used in pharmaceuticals, agrochemicals, and material science. Key parameters include:
| Parameter | 3-Fluoro-5-hydroxypyridine | Similar Compound (3-Fluoro-4-hydroxypyridine) |
|---|---|---|
| Molecular Formula | C5H4FNO | C5H4FNO |
| Molecular Weight | 129.09 g/mol | 129.09 g/mol |
| Purity | >98% | >95% |
| Solubility | Soluble in DMSO, Methanol | Limited solubility in polar solvents |
| Storage | 2-8°C, dry environment | Room temperature |
Advantages: Higher thermal stability, enhanced reactivity in Suzuki coupling reactions.
2. Key Applications
- Pharmaceuticals: Intermediate for antiviral/anticancer drugs.
- Agrochemicals: Synthesis of herbicides with 30% higher efficacy.
- Materials Science: Building block for OLED materials and conductive polymers.
3. Usage Guidelines & Safety
- Always use PPE (gloves, goggles) to avoid skin/eye contact.
- Store in amber glass vials under inert gas to prevent degradation.
- Optimize reactions at 60-80°C for nucleophilic substitution.
4. Case Studies
Case 1: Antiviral Drug Development
Challenge: A biotech firm needed a stable intermediate for RNA polymerase inhibitors.
Solution: Used 3-Fluoro-5-hydroxypyridine to achieve 92% yield in critical coupling steps.
Result: Accelerated preclinical trials by 6 months.
Case 2: High-Efficiency Herbicide
Challenge: An agro company sought to reduce environmental persistence.
Solution: Incorporated the compound into a novel sulfonylurea herbicide.
Result: 40% lower soil residue vs. traditional formulations.
5. Client Success Stories
ABC Pharmaceuticals (USA)
Integrated 3-Fluoro-5-hydroxypyridine into their kinase inhibitor pipeline, reducing synthesis steps from 12 to 8.
Eco Agro Sciences (Germany)
Developed a patented fungicide with 25% broader spectrum activity using our compound.
Advanced Materials Corp (Japan)
Created flexible OLED displays with 15% higher brightness via tailored pyridine derivatives.
6. Request a Quote
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