4-Aminopyrimidine-5-carbonitrile: Technical Overview and Applications
Table of Contents
1. Product Specifications
| Parameter | Value |
|---|---|
| CAS Number | 16357-69-0 |
| Molecular Formula | C5H4N4 |
| Molecular Weight | 120.12 g/mol |
| Purity | ≥97% |
| Synonyms | 4-Amino-5-cyanopyrimidine, 5-Cyano-4-aminopyrimidine |
Structural Note: The compound features an amino group (-NH2) at position 4 and a nitrile group (-CN) at position 5 on the pyrimidine ring, distinguishing it from positional isomers like 2-aminopyrimidine-5-carbonitrile (CAS 1753-48-6).
2. Key Applications
- Pharmaceutical Intermediates: Critical in synthesizing kinase inhibitors and antiviral agents.
- Agrochemicals: Used to develop herbicides with targeted action mechanisms.
- Material Science: Serves as a precursor for nitrogen-rich polymers.
3. Comparative Analysis
| Compound | CAS Number | Substitution Pattern | Molecular Formula |
|---|---|---|---|
| 4-Aminopyrimidine-5-carbonitrile | 16357-69-0 | 4-NH2, 5-CN | C5H4N4 |
| 2-Aminopyrimidine-5-carbonitrile | 1753-48-6 | 2-NH2, 5-CN | C5H4N4 |
| 4-Aminopyrimidine | 591-54-8 | 4-NH2 | C4H5N3 |
Note: Substitution position significantly impacts reactivity and application suitability.
4. Usage Guidelines
Storage Recommendations
- Store in airtight containers at 2-8°C
- Protect from moisture and direct sunlight
Safety Protocols
- Use PPE (gloves, goggles) during handling
- Avoid inhalation of dust particles
5. Industry Case Studies
Case Study 1: Antiviral Drug Development
Client: European Pharma Research Consortium
Application: Intermediate in nucleoside analogue synthesis
Outcome: Achieved 92% yield in final API synthesis
Case Study 2: Specialty Polymer Production
Client: Advanced Materials Inc. (USA)
Application: Precursor for high-temperature resins
Outcome: Developed polymer with 320°C thermal stability
6. Contact Information
For technical specifications or bulk inquiries:
Email: info@vivalr.com
Tel: (86) 15866781826


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