2-Fluoro-4-methylbenzaldehyde: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
2-Fluoro-4-methylbenzaldehyde (CAS 57356-71-9) is a fluorinated aromatic aldehyde with the molecular formula C8H7FO. Key parameters:
| Parameter | Value |
|---|---|
| Molecular Weight | 138.14 g/mol |
| Purity | ≥98% |
| Appearance | Clear yellow liquid |
| Boiling Point | 215-217°C |
| Storage | 2-8°C in airtight container |
Comparative Analysis
| Feature | 2-Fluoro-4-methylbenzaldehyde | 4-Methylbenzaldehyde |
|---|---|---|
| Reactivity | High (fluorine effect) | Moderate |
| Electrophilicity | Enhanced | Standard |
| Pharma Compatibility | Superior | Limited |
2. Key Applications
- Pharmaceutical Intermediates: Synthesis of kinase inhibitors and anti-inflammatory agents
- Agrochemicals: Building block for fluorinated pesticides
- Material Science: Precursor for OLED materials
- Organic Synthesis: Friedel-Crafts reactions, nucleophilic substitutions
3. Usage Scenarios
Scenario 1: API Synthesis
Used in 3-step synthesis of fluorinated COX-2 inhibitors at 78% overall yield.
Scenario 2: Cross-Coupling Reactions
Buchwald-Hartwig amination with 2-fluoro-4-methylbenzaldehyde achieved 92% conversion rate.
4. Client Case Studies
Case 1: Top 10 Pharma Company (2023)
- Application: Developed next-gen JAK inhibitor
- Result: Reduced synthesis steps from 7 to 4
- Output: 300kg batch with 99.2% HPLC purity
Case 2: Agrochemical Leader (2022)
- Usage: Fungicide intermediate production
- Benefit: 40% cost reduction vs. traditional routes
- Scale: 12-ton annual consumption
5. Contact for Inquiries
Request custom synthesis protocols or bulk pricing:
Email: info@vivalr.com
Phone: (86) 15866781826


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