3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Technical Guide

Table of Contents

1. Product Overview
2. Specifications & Comparative Analysis
3. Industrial Applications
4. Case Studies
5. Contact for Technical Consultation

1. Product Overview

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS: 151266-23-8) is a heterocyclic compound serving as a crucial intermediate in pharmaceutical synthesis. With molecular formula C₅H₅IN₅ and molecular weight 274.03 g/mol, this pyrazolopyrimidine derivative features:

• Purity: ≥98% (HPLC)
• Appearance: White to off-white crystalline powder
• Storage: 2-8°C in inert atmosphere

2. Specifications & Comparative Analysis

3. Industrial Applications

3.1 Pharmaceutical Development

As key intermediate in synthesis of:

• Ibrutinib analogs (BTK inhibitors)
• Tyrosine kinase inhibitors
• Oncology therapeutics

3.2 Chemical Research

• Structure-activity relationship (SAR) studies
• Protecting group chemistry
• Cross-coupling reactions

4. Case Studies

4.1 Shanghai Acmec Biochemical (2025)

Application: Scaled production of ibrutinib intermediates
Outcome: Achieved 92% yield in Buchwald-Hartwig amination
Scale: 50 kg batch production

4.2 Drug Discovery Program (2024)

Research: Development of selective JAK3 inhibitors
Result: Improved IC₅₀ from 18nM to 6.2nM
Publication: J.Med.Chem. 2024,67(3)

5. Contact for Technical Consultation

For analytical data sheets or custom synthesis requirements:
Email: info@vivalr.com
Phone: (86) 15866781826

Request quotation for:

• Bulk quantities (1kg+)
• Isotope-labeled derivatives
• GMP-grade material