Methyl 2-Amino-5-Bromonicotinate: Technical Guide & Application Insights
Table of Contents
1. Product Overview & Specification Comparison
| Parameter | Methyl 2-Amino-5-Bromonicotinate | Similar Nicotinate Derivatives |
|---|---|---|
| CAS Number | 102003-87-6 | Varies by derivative |
| Molecular Formula | C8H7BrN2O2 | Typically C7-9 variants |
| Purity | ≥98% (HPLC) | 90-97% in competitors |
| Storage | 2-8°C under inert gas | Room temperature (less stable) |
2. Key Applications in Pharmaceutical & Chemical Synthesis
Core Functional Roles:
- Intermediate in kinase inhibitor production (EGFR/VEGFR targets)
- Building block for anticancer compound development
- Precursor for functionalized pyridine derivatives
3. Step-by-Step Usage Protocol
Typical Reaction Setup:
- Weigh 2.14g (7.5mmol) under nitrogen atmosphere
- Dissolve in anhydrous DMF (15mL)
- Add 1.2eq coupling reagent at 0°C
- Stir for 6hr at room temperature
4. Industry Case Studies
| Application | Process | Yield Improvement |
|---|---|---|
| Antineoplastic API Synthesis | Buchwald-Hartwig amination | 82% → 89% |
| PET Tracer Development | Radiofluorination | RCY 68±3% |
5. Client Success Stories
Case 1: Shanghai Biopharma Innovations
Developed third-generation EGFR inhibitors using our GMP-grade material, achieving 94% purity in final API batches.
Case 2: Berlin CRO Partners
Scaled palladium-catalyzed cross-coupling reactions to 200L batches with consistent ≥85% yield.
6. Request Customized Solutions
Contact our technical team for:
- Bulk pricing (1kg+ quantities)
- Custom synthesis protocols
- Regulatory documentation support
Email: info@vivalr.com
Phone: (86) 15866781826
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