3-Bromo-2-pyridinamine

Product Name:3-Bromo-2-pyridinamine
CAS:13534-99-1
MFC5H5BrN2
MW:173.01
EINECS:629-620-5
MOL File:13534-99-1.mol

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Comprehensive Guide to 3-Bromo-2-pyridinamine

Table of Contents

1. Product Overview & Specifications

3-Bromo-2-pyridinamine (CAS 39856-55-2) is a brominated pyridine derivative widely used in pharmaceutical and chemical synthesis. Key parameters:

Parameter Value
Molecular Formula C5H5BrN2
Molecular Weight 173.01 g/mol
Appearance Off-white to light yellow crystalline powder
Purity ≥98% (HPLC)
Storage 2-8°C in airtight container

Comparative Analysis

Feature 3-Bromo-2-pyridinamine 2-Bromo-3-pyridinamine
Reactivity Higher in Suzuki couplings Moderate
Stability Stable under inert atmosphere Light-sensitive

2. Applications of 3-Bromo-2-pyridinamine

Pharmaceutical Intermediates

Used in synthesis of kinase inhibitors and antiviral agents.

Organic Synthesis

  • Cross-coupling reactions (e.g., Buchwald-Hartwig amination)
  • Building block for heterocyclic compounds

3. Usage Guidelines

Handling Precautions

Use in well-ventilated areas with PPE (gloves, goggles).

Reaction Optimization

Recommended conditions for coupling reactions:

  • Catalyst: Pd(dppf)Cl2
  • Temperature: 80-100°C
  • Solvent: DMF/THF mixture

4. Case Studies

Case 1: Anticancer Drug Development

Used in 7-step synthesis of a tyrosine kinase inhibitor, achieving 82% yield in key amination step.

Case 2: Material Science Research

Modified into luminescent coordination polymers for OLED applications.

5. Customer Success Stories

PharmaTech Inc. (USA)

  • Application: Hepatitis C protease inhibitor intermediate
  • Result: Reduced synthesis steps from 5 to 3
  • Feedback: “Consistent quality accelerated our preclinical trials”

EuroChem Research (Germany)

  • Application: PET tracer precursor
  • Result: Achieved 94% radiochemical purity
  • Feedback: “Critical for our diagnostic platform development”

6. Request a Quote

Contact our technical team for bulk pricing and custom synthesis:

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