2,4,6-Trifluoropyridine: Technical Guide & Application Insights
Table of Contents
1. Product Overview & Specifications
| Parameter | 2,4,6-Trifluoropyridine | Comparison with Analogues |
|---|---|---|
| CAS Number | 3512-17-2 | Unique identifier vs. similar fluoropyridines |
| Molecular Formula | C5H2F3N | Distinct fluorination pattern (2,4,6 positions) |
| Purity | ≥99% | Higher than industrial-grade alternatives (95-98%) |
| Density | 1.499 g/cm³ | Lower density vs. chlorinated derivatives |
| Boiling Point | 102-122°C (varies by measurement method) | Intermediate volatility for controlled reactions |
| Flash Point | 17-30°C (closed cup) | Requires careful handling vs. non-flammable intermediates |
Key Differentiators: Optimized fluorine substitution enhances reactivity in nucleophilic aromatic substitutions while maintaining thermal stability.
2. Key Applications
Core Use Cases:
- Pharmaceutical Intermediates: Synthesis of fluorinated active pharmaceutical ingredients (APIs)
- Agrochemicals: Building block for herbicides and fungicides
- Liquid Crystal Materials: Fluorine-containing components for electronic displays
- Cross-Coupling Reactions: Suzuki-Miyaura and Buchwald-Hartwig reactions
Performance Advantages:
- Enables precise regioselective modifications
- Enhances compound lipophilicity (LogP optimization)
- Improves metabolic stability in drug candidates
3. Usage Scenarios
Typical Process Integration:
- Handling: Use inert atmosphere (N2/Ar) due to moisture sensitivity
- Reaction Solvents: Compatible with THF, DMF, and dichloromethane
- Temperature Range: Optimal performance at 0-80°C
- Catalyst Systems: Effective with Pd(0)/Pd(II) catalysts
Safety Protocols:
- Storage: 2-8°C under inert gas
- PPE Requirements: Chemical-resistant gloves + face protection
- Emergency Measures: Neutralize spills with vermiculite/sand
4. Industry Case Studies
Case 1: Antiviral Drug Intermediate
Client: Top 10 Global Pharma Company
Application: Synthesis of fluorinated nucleoside analog
Result: 22% yield improvement vs. tribromopyridine route
Case 2: Herbicide Formulation
Client: EU Agrochem Producer
Application: Pyridine ring functionalization
Result: Achieved 99.7% regioselectivity at scale
Case 3: OLED Material Development
Client: Asian Electronics Manufacturer
Application: Electron-transport layer component
Result: 15% efficiency gain in prototype devices
5. Contact for Technical Consultation
Request custom synthesis protocols or bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826
Service Commitments:
– 24h response time for technical queries
– Batch-specific analytical reports
– Regulatory documentation support


评论
目前还没有评论。