2-Chloro-3-pyridylboronic acid

2-Chloro-3-pyridylboronic Acid: Comprehensive Product Guide

Table of Contents

• Product Specifications & Comparative Analysis
• Applications in Pharmaceutical & Industrial Chemistry
• Synthesis Protocols & Handling Guidelines
• Case Studies in Drug Development
• Client Success Stories
• Request Customized Quotes

1. Technical Specifications & Supplier Comparison

2. Key Industrial Applications

Pharmaceutical Intermediates

Critical precursor in kinase inhibitors (e.g., Crizotinib analogs) and antiviral agents. Enables precise regioselectivity in Suzuki-Miyaura cross-couplings for API development.

Agrochemical Synthesis

Essential building block for neonicotinoid insecticides like Clothianidin derivatives. Enhances binding affinity to insect nicotinic acetylcholine receptors.

3. Recommended Synthetic Protocols

Optimized Coupling Conditions

Reaction matrix: 1.2 eq. boronic acid, Pd(PPh3)4 (3 mol%), K2CO3 (2M aq.), DME/H2O (3:1), 80°C under N2. Typical yields: 72-85%.

4. Implementation Case Studies

Case 1: Anticancer Drug Intermediate

Used in 8-step synthesis of ALK/ROS1 inhibitor analogs. Achieved 92% HPLC purity at final API stage through controlled coupling efficiency.

5. Verified Client Implementations

PharmaTech Solutions (Germany)

Scaled production of JAK2 inhibitors using 2-chloro-3-pyridylboronic acid batches. Reported 18% yield improvement versus previous boronic acid suppliers.

AgroGuard Ltd. (USA)

Developed next-generation systemic insecticides with 40% higher field efficacy using Vivalr-sourced material in lead optimization phases.

6. Request Technical Documentation

Contact our chemistry team for batch-specific COA, MSDS, and custom synthesis options:

Email: info@vivalr.com
Tel: (86) 15866781826