4,6-Dichloronicotinic acid

Comprehensive Guide to 4,6-Dichloronicotinic Acid

Table of Contents

• 1. Product Overview & Specifications
• 2. Key Applications & Industry Uses
• 3. Technical Comparison with Alternatives
• 4. Operational Best Practices
• 5. Real-World Case Studies
• 6. Contact for Custom Solutions

1. Product Overview & Specifications

4,6-Dichloronicotinic Acid (CAS 28844-21-5) is a chlorinated derivative of nicotinic acid with molecular formula C₆H₃Cl₂NO₂. Technical parameters:

Comparative Analysis

2. Key Applications & Industry Uses

Pharmaceutical Intermediates

Critical precursor for:

• Antiviral drug synthesis (e.g., reverse transcriptase inhibitors)
• Kinase inhibitor development
• Metabolite analogs in cancer research

Agrochemical Production

• Herbicide metabolites
• Fungicide intermediates
• Plant growth regulator synthesis

Industrial Applications

• Coordination chemistry ligands
• Polymer modification agents
• Advanced material precursors

3. Technical Comparison with Alternatives

4. Operational Best Practices

Handling Protocols

• Use nitrogen atmosphere for sensitive reactions
• Maintain pH 6.5-7.5 in aqueous solutions
• Optimize reaction temps between 60-80°C

Safety Considerations

• PPE Requirement: Nitrile gloves, chemical goggles
• Spill Management: Absorb with vermiculite
• Storage Compatibility: Avoid strong oxidizers

5. Real-World Case Studies

Case 1: European Pharma Innovator

Client: Top 10 EU Drug Developer
Challenge: Required high-purity intermediate for Phase III trial material
Solution: Customized 99.2% pure batch with <1% isomer content
Outcome: Accelerated regulatory approval by 14 months

Case 2: Asian Agrochemical Leader

Client: Regional Market Leader
Challenge: Needed cost-effective alternative to brominated analogs
Solution: Optimized chlorination process reducing production costs by 32%
Result: Achieved 18% market share gain in 2 years

6. Contact for Custom Solutions

Our technical team specializes in:

• Bulk quantities (100kg+ drum orders)
• Custom purity profiles (95-99.9%)
• GMP-compliant manufacturing

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