2,5-Difluoropyridine

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2,5-Difluoropyridine: Comprehensive Product Guide

1. Product Specifications & Comparative Analysis

Parameter 2,5-Difluoropyridine Similar Compounds
CAS Number 84476-99-3 N/A
Molecular Formula C5H3F2N C5H4FN (2-Fluoropyridine)
Molecular Weight 115.08 g/mol 97.09 g/mol
Density 1.274 g/mL 1.13 g/mL
Boiling Point 113.1–115°C 92–94°C
Melting Point -33°C -70°C
Flash Point 22.2–75.2°F 40°F
Purity ≥98% ≥95%

Storage: 2–8°C in sealed containers

Safety: GHS02 (Flammable), GHS07 (Irritant)

2. Key Applications

Pharmaceutical Intermediates

  • Synthesis of kinase inhibitors
  • Anticancer drug development
  • API manufacturing

Agrochemicals

  • Herbicide formulations
  • Pesticide intermediates

Electronics

  • Liquid crystal precursor
  • Semiconductor material synthesis

3. Operational Guidelines

Handling Protocols

  • Use PPE: Nitrile gloves, chemical goggles
  • Operate under fume hood
  • Ground equipment to prevent static

Reaction Optimization

  • Optimal temperature: 25–40°C
  • Compatible solvents: DCM, THF, EtOAc
  • Catalyst compatibility: Pd/C, CuI

4. Industry Use Cases

Case A: Antineoplastic Agent Synthesis

Used in 5-step synthesis of EGFR inhibitors with 72% overall yield.

Case B: Crop Protection Chemicals

Key intermediate in next-gen herbicides with 40% improved efficacy.

5. Client Success Stories

PharmaTech Innovations (Shanghai)

  • Application: PARP inhibitor development
  • Result: Accelerated Phase I trials by 18 months
  • Volume: 500 kg/year

AgroSolutions Ltd. (Wuhan)

  • Application: Fungicide formulation
  • Result: Achieved 99.5% purity in final API
  • Volume: 1.2 MT/year

6. Request Quotation

For bulk pricing (25kg+), custom synthesis, or technical support:

Email: info@vivalr.com

Tel: (86) 15866781826

Lead Time: 3–5 business days for samples

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