BENZO[B]THIOPHENE-2-CARBOXALDEHYDE: Comprehensive Guide
Table of Contents
- 1. Product Overview & Specifications
- 2. Applications & Use Cases
- 3. Parameter Comparison with Similar Compounds
- 4. Industry-Specific Case Studies
- 5. Client Success Stories
- 6. Request a Quote or Technical Support
1. Product Overview & Specifications
BENZO[B]THIOPHENE-2-CARBOXALDEHYDE (CAS 13677-68-4) is a heterocyclic aromatic aldehyde widely used in pharmaceutical and material science research. Key specifications:
| Parameter | Value |
|---|---|
| Molecular Formula | C9H6OS |
| Molecular Weight | 162.21 g/mol |
| Purity | >98% (HPLC) |
| Appearance | Yellow crystalline powder |
| Melting Point | 102-105°C |
| Storage | 2-8°C in airtight container |
2. Applications & Use Cases
2.1 Pharmaceutical Intermediate
Used in synthesis of kinase inhibitors and anticancer agents due to its electron-deficient aromatic system.
2.2 Material Science
Key precursor for organic semiconductors in OLED devices (e.g., hole-transport layers).
2.3 Organic Synthesis
Participates in:
– Suzuki-Miyaura cross-coupling reactions
– Knoevenagel condensations
– Schiff base formations
3. Parameter Comparison
| Compound | Reactivity | Solubility | Thermal Stability |
|---|---|---|---|
| BENZO[B]THIOPHENE-2-CARBOXALDEHYDE | High | Soluble in THF, DMF | Stable ≤150°C |
| Thiophene-2-carboxaldehyde | Moderate | Soluble in ethanol | Stable ≤130°C |
| Benzaldehyde | Low | Soluble in ether | Stable ≤180°C |
4. Industry-Specific Case Studies
4.1 Antiviral Drug Development
A research team synthesized novel protease inhibitors using this aldehyde as key intermediate, achieving 78% yield in palladium-catalyzed coupling reactions.
4.2 Flexible Electronics
Material engineers created a thiophene-based polymer with 15% higher charge mobility than standard PEDOT:PSS, enabled by the aldehyde’s planar structure.
5. Client Success Stories
5.1 PharmaCorp (USA)
Challenge: Needed high-purity aldehyde for scale-up synthesis of Phase III oncology candidate.
Solution: Supplied 25kg batch with >99% HPLC purity under cGMP conditions.
Result: Reduced impurity levels from 2.1% to 0.3% in final API.
5.2 EuroMaterials GmbH
Challenge: Required customized particle size (D90 <50μm) for thin-film deposition.
Solution: Developed micronized form with 45±5μm particle distribution.
Result: Achieved 92% coating uniformity in pilot production.
6. Get Expert Support
For pricing, bulk orders, or technical specifications:
Email: info@vivalr.com
Phone: (86) 15866781826
Why choose us?
– Batch-to-batch consistency (RSD <1.5%)
– Custom synthesis capabilities
– 24/7 technical support


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