BENZO[B]THIOPHENE-2-CARBOXALDEHYDE

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BENZO[B]THIOPHENE-2-CARBOXALDEHYDE: Comprehensive Guide

Table of Contents

1. Product Overview & Specifications

BENZO[B]THIOPHENE-2-CARBOXALDEHYDE (CAS 13677-68-4) is a heterocyclic aromatic aldehyde widely used in pharmaceutical and material science research. Key specifications:

Parameter Value
Molecular Formula C9H6OS
Molecular Weight 162.21 g/mol
Purity >98% (HPLC)
Appearance Yellow crystalline powder
Melting Point 102-105°C
Storage 2-8°C in airtight container

2. Applications & Use Cases

2.1 Pharmaceutical Intermediate

Used in synthesis of kinase inhibitors and anticancer agents due to its electron-deficient aromatic system.

2.2 Material Science

Key precursor for organic semiconductors in OLED devices (e.g., hole-transport layers).

2.3 Organic Synthesis

Participates in:
– Suzuki-Miyaura cross-coupling reactions
– Knoevenagel condensations
– Schiff base formations

3. Parameter Comparison

Compound Reactivity Solubility Thermal Stability
BENZO[B]THIOPHENE-2-CARBOXALDEHYDE High Soluble in THF, DMF Stable ≤150°C
Thiophene-2-carboxaldehyde Moderate Soluble in ethanol Stable ≤130°C
Benzaldehyde Low Soluble in ether Stable ≤180°C

4. Industry-Specific Case Studies

4.1 Antiviral Drug Development

A research team synthesized novel protease inhibitors using this aldehyde as key intermediate, achieving 78% yield in palladium-catalyzed coupling reactions.

4.2 Flexible Electronics

Material engineers created a thiophene-based polymer with 15% higher charge mobility than standard PEDOT:PSS, enabled by the aldehyde’s planar structure.

5. Client Success Stories

5.1 PharmaCorp (USA)

Challenge: Needed high-purity aldehyde for scale-up synthesis of Phase III oncology candidate.
Solution: Supplied 25kg batch with >99% HPLC purity under cGMP conditions.
Result: Reduced impurity levels from 2.1% to 0.3% in final API.

5.2 EuroMaterials GmbH

Challenge: Required customized particle size (D90 <50μm) for thin-film deposition.
Solution: Developed micronized form with 45±5μm particle distribution.
Result: Achieved 92% coating uniformity in pilot production.

6. Get Expert Support

For pricing, bulk orders, or technical specifications:
Email: info@vivalr.com
Phone: (86) 15866781826

Why choose us?
– Batch-to-batch consistency (RSD <1.5%)
– Custom synthesis capabilities
– 24/7 technical support

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