5-Bromo-2-fluoro-3-pyridylboronic Acid: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
5-Bromo-2-fluoro-3-pyridylboronic Acid (CAS: 1072951-97-7) is a premium boronic acid derivative with molecular formula C5H4BBrFNO2 and molecular weight 243.81 g/mol. Key parameters:
| Parameter | Specification | Industry Standard |
|---|---|---|
| Purity | ≥98% (HPLC) | ≥95% |
| Melting Point | 185-190°C | 180-195°C |
| Solubility | Soluble in DMF, DMSO | Partial solubility |
2. Applications & Use Cases
Core Applications:
- Suzuki-Miyaura cross-coupling reactions
- Pharmaceutical intermediates (kinase inhibitors)
- OLED material synthesis
Reaction Example:
Ar-B(OH)2 + R-X → Ar-R + B(OH)2X
(Where X = Br, I, OTf)
3. Performance Comparison
| Competitor Product | Reaction Yield | Our Product Yield |
|---|---|---|
| Generic Boronic Acids | 65-75% | 82-89% |
| Fluorinated Derivatives | 70-78% | 85-91% |
4. Customer Success Stories
Case 1: Vertex Pharmaceuticals
Application: Development of EGFR inhibitor candidates
Result: Achieved 88% coupling efficiency in lead compound synthesis
Case 2: Merck KGaA
Application: OLED emitter material R&D
Result: Enhanced luminescence efficiency by 22% vs previous materials
5. Request Customized Solutions
Contact our technical team for:
- Bulk pricing (1kg+ orders)
- Custom purity requirements
- Technical documentation
Email: info@vivalr.com
Phone: (86) 15866781826
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