2-Bromo-5-fluoro-6-methylpyridine

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2-Bromo-5-fluoro-6-methylpyridine: Comprehensive Guide

Table of Contents

1. Product Overview & Specifications

Parameter Specification
CAS Number 1261542-61-4
Molecular Formula C6H4BrFN
Molecular Weight 204.01 g/mol
Appearance White to off-white crystalline powder
Purity (HPLC) ≥98.5%
Storage Conditions 2-8°C in inert atmosphere

2. Key Applications & Industry Use Cases

Pharmaceutical Intermediate

Critical building block for kinase inhibitors in oncology therapeutics (e.g., EGFR/HER2 inhibitors)

Agrochemical Synthesis

Key precursor in next-generation fungicides with enhanced environmental stability

Material Science

Used in conductive polymer synthesis for flexible electronics (OLED manufacturing)

3. Operational Guidelines & Safety Protocols

Handling Requirements

  • Use nitrile gloves & chemical goggles
  • Maintain fume hood ventilation ≥0.5 m/s

Reactivity Profile

  • Incompatible with strong oxidizers
  • Avoid contact with magnesium alloys

4. Comparative Analysis with Alternatives

Compound Reactivity Cost Efficiency Synthetic Yield
2-Bromo-5-fluoro-6-methylpyridine High ★★★☆☆ 82-88%
2-Chloro-5-fluoropyridine Medium ★★☆☆☆ 75-80%
5-Bromo-2-fluoropyridine Low ★★★★☆ 68-72%

5. Client Case Studies (2023-2024)

Case 1: Oncology Drug Development

Client: Top 10 Global Pharma Company
Application: Synthesized third-generation EGFR inhibitor
Result: Achieved 92% reaction selectivity in lead compound

Case 2: Advanced Crop Protection

Client: EU Agrochemical Manufacturer
Application: Developed systemic fungicide with 40% longer field persistence
Result: Reduced application frequency from 3x to 2x per season

6. Request Customized Quotation

Contact our technical team for batch-specific COA and GMP-grade pricing:

※ Specify required quantity, purity grade (98%/99%/99.5%), and preferred packaging

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