2-Amino-4-hydroxy-6-phenylpyrimidine

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2-Amino-4-hydroxy-6-phenylpyrimidine: Technical Guide & Application Solutions

Parameter	2-Amino-4-hydroxy-6-phenylpyrimidine	Conventional Pyrimidines
CAS Number	5467-70-9	Varies
Molecular Formula	C₁₀H₉N₃O	Typically C₄H₄N₂
Purity Grade	≥99% (HPLC)	85-95%
Solubility	DMSO: 50 mg/mL, Water: <0.1 mg/mL	Limited organic solubility

Key Advantage: Enhanced stability in alkaline conditions (pH 9-12) compared to standard pyrimidine derivatives.

Essential in synthesizing kinase inhibitors, particularly JAK2 and EGFR inhibitors, with 32% higher yield efficiency than analogous compounds.

Core component in next-generation fungicides, demonstrating 98.7% efficacy against Botrytis cinerea at 50 ppm concentration.

Used in 6-step synthesis of Ponatinib analogues, achieving 89% enantiomeric excess in final products.

Integrated into cystic fibrosis drug development pipeline, reducing synthesis steps from 11 to 7 with 40% cost reduction.

Enabled creation of broad-spectrum fungicide with 21-day residual activity, passing OECD 201/202 guidelines.

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类别 chem