Table of Contents
- 1. Product Information & Specifications
- 2. Key Applications & Industrial Uses
- 3. Usage Guidelines & Handling Procedures
- 4. Application Case Studies
- 5. Verified Client Implementations
- 6. Request Customized Solutions
1. Product Information & Specifications
Basic Parameters
| Parameter | Specification |
|---|---|
| CAS Number | 874285-61-3 |
| Molecular Formula | C4HClFN2O |
| Molecular Weight | 146.52 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity (HPLC) | ≥99.0% |
| Melting Point | 142-145°C |
| Storage Conditions | 2-8°C in inert atmosphere |
Comparative Analysis
| Feature | 2-Chloro-5-fluoropyrimidin-4-one | Standard Pyrimidine Derivatives |
|---|---|---|
| Reactivity | High (Dual activating groups) | Moderate |
| Synthetic Flexibility | 3 reactive sites for functionalization | Typically 1-2 sites |
| Pharma Compatibility | Preferred for kinase inhibitors | Limited target specificity |
| Thermal Stability | Stable up to 150°C | Degrades above 120°C |
2. Key Applications & Industrial Uses
Pharmaceutical Intermediates
Essential building block for:
- Tyrosine kinase inhibitor precursors
- Anticancer drug candidates (Phase II/III compounds)
- Antiviral agent molecular frameworks
Agrochemical Development
Critical component in:
- Next-generation fungicides
- Herbicide resistance management formulations
- Plant growth regulator synthesis
3. Usage Guidelines & Handling Procedures
Synthetic Protocols
Recommended reaction conditions:
| Reaction Type | Conditions | Yield Range |
|---|---|---|
| Nucleophilic Substitution | DCM, 0-5°C, N2 atmosphere | 78-85% |
| Cross Coupling | Pd(PPh3)4, THF, 60°C | 65-72% |
4. Application Case Studies
Case 1: Antineoplastic Agent Development
Used in 9-step synthesis of EGFR inhibitor:
- Key Suzuki coupling reaction substrate
- Improved reaction efficiency by 40% vs alternatives
- Current status: IND-enabling studies
5. Verified Client Implementations
European Pharma Leader (Confidential)
- Application: Kinase inhibitor scaffold development
- Consumption: 120kg/year (GMP grade)
- Result: Accelerated lead optimization by 6 months
US Agrochemical Innovator
- Usage: Systemic fungicide active ingredient
- Scale: 500kg pilot batch production
- Outcome: 92% disease suppression in field trials
6. Request Customized Solutions
Contact our technical team:
- Email: info@vivalr.com
- Phone: (86) 15866781826
- Available Services:
- Custom synthesis (100g to 100kg scale)
- Stable isotope-labeled variants
- Regulatory support documentation
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