3-AMINO-6-CHLORO-4-PICOLINE

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3-Amino-6-Chloro-4-Picoline: Comprehensive Product Guide

1. Product Overview & Specifications

CAS No.: 66909-38-4

IUPAC Name: 3-Amino-6-chloro-4-methylpyridine

Synonyms: 2-Chloro-5-amino-4-methylpyridine; 6-Chloro-4-methylpyridin-3-amine

Physical Properties

Property Value
Appearance Bordeaux to brown crystalline powder
Melting Point 69–73°C
Boiling Point 309.7°C at 760 mmHg
Density 1.26 g/cm³
Refractive Index 1.592
Flash Point 141.1°C

2. Key Applications

  • Pharmaceutical Intermediates: Used in synthesizing active pharmaceutical ingredients (APIs) for antiviral and anticancer drugs.
  • Agrochemicals: Key component in pesticide formulations targeting crop pathogens.
  • Material Science: Building block for advanced polymers and coordination complexes.
  • Analytical Chemistry: Chelating agent for spectrophotometric determination of transition metals.

3. Usage Guidelines

Storage: Store in a cool, dry place (2–8°C) under inert atmosphere. Shelf life: 24 months.

Handling: Use PPE (gloves, goggles) in well-ventilated areas. Avoid contact with strong oxidizers.

Solubility: Soluble in ethanol, DMSO, and dichloromethane; sparingly soluble in water.

4. Industry Case Studies

Case 1: Antiviral Drug Development

A European pharmaceutical company utilized this compound as a critical intermediate in synthesizing a novel RNA polymerase inhibitor, achieving 98.5% purity in final API batches.

Case 2: Polymer Catalyst Synthesis

A materials research institute developed a nickel-based coordination catalyst using 3-amino-6-chloro-4-picoline, enhancing catalytic efficiency by 40% in cross-coupling reactions.

5. Client Success Stories

Client A: Top-10 Global Pharma Company

Integrated this compound into their HCV drug pipeline, reducing synthesis steps from 7 to 4 while maintaining >99% enantiomeric purity.

Client B: Specialty Chemicals Manufacturer

Scaled production of corrosion-resistant coatings using our product, achieving 200-ton/year capacity with 99.2% batch consistency.

6. Request a Quote

Contact our technical team for pricing, bulk orders, or custom synthesis:

Email info@vivalr.com
Phone (86) 15866781826
Lead Time 7–14 days (standard orders)
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