4-Methylpyridine: Comprehensive Technical Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | Specification |
|---|---|
| Chemical Formula | C6H7N |
| Molecular Weight | 93.13 g/mol |
| CAS Number | 108-89-4 |
| Appearance | Colorless liquid |
| Boiling Point | 145°C |
| Melting Point | 3.6°C |
| Density | 0.957 g/mL at 25°C |
| Flash Point | 56.7°C (closed cup) |
| Solubility | Miscible with water, ethanol, ether |
2. Key Applications
Core Industrial Uses:
- Pharmaceuticals: Key intermediate for Isoniazid (tuberculosis treatment) and antidotes (Obidoxime, Pralidoxime)
- Agrochemicals: Synthesis of pyrethroid insecticides and herbicide intermediates
- Polymer Industry: Production of rubber vulcanization accelerators and resin modifiers
- Chemical Synthesis: Precursor for 4-picoline N-oxide and metal coordination complexes
- Specialty Solvents: High-polarity solvent for organic reactions
3. Physical & Chemical Properties
| Property | Value |
|---|---|
| Vapor Pressure | 4 mmHg @ 20°C |
| Refractive Index | 1.504 @ 20°C |
| pKa | 6.02 |
| Autoignition Temp. | Not established |
| Explosion Limits | 1.3% (LEL) – 8.7% (UEL) |
4. Safety & Handling
Hazard Classification (GHS):
- Flammable Liquid Category 3
- Acute Toxicity (Oral/Skin/Inhalation) Category 3-4
- Skin/Eye Irritation Category 2
Protective Measures:
| Exposure Route | Protection Protocol |
|---|---|
| Inhalation | Use NIOSH-approved respirator above exposure limits |
| Skin Contact | Chemical-resistant gloves (Butyl rubber recommended) |
| Eye Protection | Goggles with face shield |
| Storage | Flame-proof area with secondary containment |
5. Industry Use Cases
Documented Applications:
- Pharmaceutical Manufacturing: Multi-ton scale production of anti-TB drugs in China
- Electroplating Industry: Component in zinc alloy plating baths (Japan)
- Research Institutions: Ligand in catalytic systems for cross-coupling reactions
6. Regulatory Compliance
| Regulation | Status |
|---|---|
| REACH | Fully registered |
| TSCA | Listed |
| DOT Classification | UN2313, PG III |
| China GHS | Controlled chemical (危化品经营许可证 required) |
7. Contact for Technical Inquiry
For commercial samples or technical specifications:
Email: info@vivalr.com
Tel: (86) 15866781826
Procurement Notice:
Valid Hazardous Chemical Operation License required for purchase.
Transportation must comply with ADR/RID/IMDG/IATA regulations.
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