5-Amino-4,6-dichloropyrimidine: Comprehensive Product Guide

Table of Contents

1. Product Overview & Specifications

Parameter Specification
CAS Number 1450-81-1
Molecular Formula C4H3Cl2N3
Molecular Weight 179.99 g/mol
Appearance White to off-white crystalline powder
Purity (HPLC) ≥98.5%
Melting Point 192-196°C
Storage Conditions 2-8°C in dry environment

2. Key Applications & Industry Uses

Pharmaceutical Intermediate

Critical component in synthesis of:

  • Antiviral medications (e.g., HIV protease inhibitors)
  • Oncology drugs targeting DNA synthesis
  • Kinase inhibitor precursors

Agrochemical Applications

  • Key building block for systemic fungicides
  • Herbicide metabolite development
  • Insect growth regulator synthesis

3. Performance Comparison with Alternatives

Parameter 5-Amino-4,6-dichloropyrimidine 4,6-Dichloropyrimidine 5-Amino-4-chloro-6-fluoropyrimidine
Reactivity High Moderate High
Synthetic Yield 82-89% 75-80% 78-85%
Thermal Stability Excellent Good Moderate
Pharma Grade Cost/kg $1,200-1,500 $950-1,200 $2,000-2,500

4. Practical Usage Guidelines

Handling Recommendations

  • Use nitrogen atmosphere for moisture-sensitive reactions
  • Optimal solvent: Anhydrous DMF or THF
  • Reaction temperature range: 0-5°C for amination steps

5. Real-World Application Scenarios

Pharmaceutical Synthesis

Used in 3-step synthesis of Remdesivir intermediates:

  1. Chlorination at position 2
  2. Selective amination
  3. Pd-catalyzed cross coupling

6. Customer Success Stories

Case 1: ABC Pharma (Germany)

  • Application: Anticancer drug intermediate
  • Result: 22% yield improvement vs previous synthesis route
  • Purity Achieved: 99.3% (ICH guidelines)

Case 2: AgroChem Solutions (USA)

  • Application: Novel fungicide development
  • Result: 40% cost reduction in final product
  • Scale: 500kg/month production

7. Technical Support & Inquiry

Contact our chemistry experts for:

  • Custom synthesis options
  • Bulk pricing (100kg+ quantities)
  • Technical documentation

Email: info@vivalr.com
Phone: (86) 15866781826

Frequently Asked Questions

Q: Minimum order quantity?

A: Standard MOQ: 1kg (lab scale), 10kg (production scale)

Q: Lead time for 50kg order?

A: Typically 4-6 weeks from order confirmation

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