5-AMINO-3-BROMO-2-METHOXYPYRIDINE: Technical Guide & Procurement Insights
Table of Contents
- Product Overview & Specifications
- Key Applications & Industrial Uses
- Performance Comparison With Analogues
- Case Studies in Pharmaceutical R&D
- Client Success Stories
- Request Customized Quotation
1. Product Overview & Specifications
CAS Number: 53242-18-5
IUPAC Name: 5-Amino-3-bromo-2-methoxypyridine
Molecular Formula: C6H7BrN2O
Molecular Weight: 215.04 g/mol
HS Code: 29333990 (India import classification)
Appearance: Off-white to pale yellow crystalline powder
Key Parameters Comparison
| Property | 5-Amino-3-bromo-2-methoxypyridine | 3-Amino-5-bromo-2-methylpyridine |
|---|---|---|
| CAS Number | 53242-18-5 | 914358-73-9 |
| Molecular Weight | 215.04 | 187.04 |
| Reactivity | Electrophilic substitution at position 6 | Nucleophilic aromatic substitution |
2. Key Applications & Industrial Uses
- Pharmaceutical intermediate for kinase inhibitor development
- Building block in agrochemical synthesis
- Coordination ligand in catalytic systems
- Precursor for PET radiotracer compounds
3. Performance Comparison With Analogues
| Compound | Synthetic Yield | Thermal Stability | Solubility (DMSO) |
|---|---|---|---|
| 5-Amino-3-bromo-2-methoxypyridine | 82-88% | Stable up to 150°C | 85 mg/mL |
| 5-Bromo-2-methoxy-3-nitropyridine | 75-80% | Decomposes at 110°C | 45 mg/mL |
4. Case Studies in Pharmaceutical R&D
4.1 JAK2 Inhibitor Development
Used as core structure in selective Janus kinase 2 inhibitor synthesis through Buchwald-Hartwig amination, achieving IC50 of 12 nM.
4.2 Antibacterial Agent Optimization
Served as key intermediate in fluoroquinolone derivatives showing 8× improved potency against Gram-positive pathogens compared to ciprofloxacin.
5. Client Success Stories
5.1 Top 10 Pharma Company (Confidential)
- Application: Oncology drug intermediate
- Quantity: 150 kg/year
- Purity Requirement: >99.5%
- Outcome: Enabled scale-up to Phase III clinical trials
5.2 European CRO Specialist
- Usage: Library compound for high-throughput screening
- Project Scope: 320 derivative compounds
- Result: Identified 3 lead compounds with antiviral activity
6. Request Customized Quotation
Contact our technical team for batch-specific COA, bulk pricing, and regulatory support:
Email: info@vivalr.com
Phone: (86) 15866781826


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