5-AMINO-3-BROMO-2-METHOXYPYRIDINE

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5-AMINO-3-BROMO-2-METHOXYPYRIDINE: Technical Guide & Procurement Insights

Table of Contents

1. Product Overview & Specifications

CAS Number: 53242-18-5
IUPAC Name: 5-Amino-3-bromo-2-methoxypyridine
Molecular Formula: C6H7BrN2O
Molecular Weight: 215.04 g/mol
HS Code: 29333990 (India import classification)
Appearance: Off-white to pale yellow crystalline powder

Key Parameters Comparison

Property 5-Amino-3-bromo-2-methoxypyridine 3-Amino-5-bromo-2-methylpyridine
CAS Number 53242-18-5 914358-73-9
Molecular Weight 215.04 187.04
Reactivity Electrophilic substitution at position 6 Nucleophilic aromatic substitution

2. Key Applications & Industrial Uses

  • Pharmaceutical intermediate for kinase inhibitor development
  • Building block in agrochemical synthesis
  • Coordination ligand in catalytic systems
  • Precursor for PET radiotracer compounds

3. Performance Comparison With Analogues

Compound Synthetic Yield Thermal Stability Solubility (DMSO)
5-Amino-3-bromo-2-methoxypyridine 82-88% Stable up to 150°C 85 mg/mL
5-Bromo-2-methoxy-3-nitropyridine 75-80% Decomposes at 110°C 45 mg/mL

4. Case Studies in Pharmaceutical R&D

4.1 JAK2 Inhibitor Development

Used as core structure in selective Janus kinase 2 inhibitor synthesis through Buchwald-Hartwig amination, achieving IC50 of 12 nM.

4.2 Antibacterial Agent Optimization

Served as key intermediate in fluoroquinolone derivatives showing 8× improved potency against Gram-positive pathogens compared to ciprofloxacin.

5. Client Success Stories

5.1 Top 10 Pharma Company (Confidential)

  • Application: Oncology drug intermediate
  • Quantity: 150 kg/year
  • Purity Requirement: >99.5%
  • Outcome: Enabled scale-up to Phase III clinical trials

5.2 European CRO Specialist

  • Usage: Library compound for high-throughput screening
  • Project Scope: 320 derivative compounds
  • Result: Identified 3 lead compounds with antiviral activity

6. Request Customized Quotation

Contact our technical team for batch-specific COA, bulk pricing, and regulatory support:

Email: info@vivalr.com
Phone: (86) 15866781826

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