Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
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5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents
3-Amino-5-bromo-2-chloropyridine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | 3-Amino-5-bromo-2-chloropyridine |
| CAS Number | 588729-99-1 |
| Molecular Formula | C5H4BrClN2 |
| Molecular Weight | 207.456 g/mol |
| Density | 1.8±0.1 g/cm³ |
| Boiling Point | 296.8±35.0 °C |
| Flash Point | 133.3±25.9 °C |
| Refractive Index | 1.648 |
Key Features: High-purity intermediate (≥99%) with stability under controlled storage (4°C, protected from light).
2. Applications & Industrial Uses
Core Applications:
- Pharmaceutical Intermediates: Critical in synthesizing active pharmaceutical ingredients (APIs) for antiviral and anticancer drugs.
- Agrochemicals: Used to develop herbicides and fungicides due to its halogenated pyridine backbone.
- Dye Manufacturing: Serves as a precursor for lightfast organic dyes in textiles and coatings.
- Organic Synthesis: Facilitates cross-coupling reactions (e.g., Suzuki-Miyaura) in research and industrial processes.
3. Operational Guidelines
Recommended Workflow:
- Storage: Store at 4°C in airtight, light-resistant containers. Avoid prolonged exposure to moisture.
- Handling: Use PPE (gloves, goggles, lab coat) in fume hoods to minimize inhalation/contact risks.
- Reaction Conditions: Optimize at temperatures below 200°C to prevent decomposition. Compatible with THF, DCM, and DMF solvents.
4. Safety & Handling Protocols
| Hazard | Precaution |
|---|---|
| Skin/Irritation | Wash immediately with soap/water. Seek medical attention if irritation persists. |
| Eye Exposure | Rinse eyes with water for 15 minutes. Remove contact lenses if present. |
| Inhalation | Move to fresh air. Administer oxygen if breathing difficulties occur. |
GHS Classification: Skin Irritant (Category 2), Eye Damage (Category 2A).
5. Client Case Studies
Case Study 1: Pharmaceutical R&D Firm
Challenge: Required a stable intermediate for a kinase inhibitor synthesis.
Solution: Integrated 3-Amino-5-bromo-2-chloropyridine into Pd-catalyzed coupling steps, achieving 92% yield.
Case Study 2: Agrochemical Manufacturer
Challenge: Needed a cost-effective precursor for a novel fungicide.
Solution: Scaled up production using this compound, reducing synthesis steps by 30%.
6. Contact for Quotation
Request pricing, bulk orders, or technical support:
- Email: info@vivalr.com
- Phone: (86) 15866781826
