Parameter | 3-Amino-2-fluoropyridine | Comparable Compound |
---|---|---|
CAS Number | 374-52-5 | 2-Amino-3-fluoropyridine (CAS 374-51-4) |
Molecular Formula | C5H5FN2 | C5H5FN2 |
Molecular Weight | 112.11 g/mol | 112.11 g/mol |
Appearance | White to off-white crystalline powder | Pale yellow crystals |
Purity | ≥98% (HPLC) | ≥95% |
Pharmaceutical Intermediates: Key building block for kinase inhibitors and EGFR-targeting drugs
Agrochemical Synthesis: Precursor for novel pyridine-based pesticides
Material Science: Ligand in coordination chemistry for catalytic systems
Storage Conditions: Keep in cool, dry environment (2-8°C) under inert atmosphere
Handling Precautions: Use nitrogen glove boxes for air-sensitive reactions
Anticancer Drug Development: Used in third-generation EGFR inhibitor synthesis (2023 clinical trials)
Crop Protection Formulation: Demonstrated 40% efficacy improvement in fungicide formulations
Case 1: PharmaHealth Innovations (USA) - Scaled production for BTK inhibitor API
Application | Result | Duration |
---|---|---|
Process Optimization | Yield increased from 68% to 82% | Q3 2022-Q1 2023 |
Case 2: AgroChem Solutions (Germany) - Developed new chloropyridine fungicide
Parameter | Before | After |
---|---|---|
Dosage Requirement | 2.5g/ha | 1.8g/ha |
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