2,4-Dibromopyridine

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2,4-Dibromopyridine: Technical Guide, Applications, and Case Studies

2,4-Dibromopyridine (CAS 3116-81-4) is a halogenated pyridine derivative with molecular formula C₅H₃Br₂N. Key parameters:

Parameter	Specification	Competitor A	Competitor B
Purity	≥99%	≥98%	≥97.5%
Melting Point	60-63°C	58-61°C	59-62°C
Bromine Content	64.2%	63.8%	63.5%

Pharmaceutical Intermediates: Critical precursor for kinase inhibitors and antiviral agents
Agrochemical Synthesis: Building block for crop protection chemicals
Ligand Preparation: Used in transition metal catalysis systems
Material Science: Functional group for OLED materials

As coupling partner in Pd-catalyzed reactions for biaryl compound synthesis:

2,4-Dibromopyridine + Arylboronic Acid → 2-Aryl-4-bromopyridine

Selective bromine substitution enables targeted modification of drug candidates:

Step 1: 2,4-Dibromopyridine → 2-Bromo-4-aminopyridine
Step 2: Subsequent functionalization for kinase inhibition

Challenge: Required high-purity intermediate for Phase III trial compound
Solution: Supplied 99.2% purity 2,4-Dibromopyridine with <0.1% residual solvents
Result: Accelerated API synthesis timeline by 18%

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类别 chem